67544-77-8Relevant academic research and scientific papers
A facile three-step synthesis of (±)-crispine A via an acyliminium ion cyclisation
King, Frank D.
, p. 2053 - 2056 (2007/10/03)
A high yielding cyclisation of the readily available N-(4,4-diethoxybutyl)-2-(3,4-dimethoxyphenyl)acetamide to 8,9-bis(methyloxy)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-o ne is described. The latter can be reduced with either AlH3
N,N-DIACYLPIPERAZINES
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, (2008/06/13)
Diacylpiperazines of general structural formula: STR1 are: angiotensin II (A-II) antagonists with affinity for both AT 1 and AT. sub.2 receptors useful in the treatment of hypertension, congestive heat failure, cerebrovascular, cognitive, and CNS disorders.
N,N-diacylpiperazines
-
, (2008/06/13)
Diacylpiperazines of general structure STR1 are: angiotensin II (A-II) antagonists selective for the type 2 (AT 2) subtype useful in the treatment of cerebrovascular, cognitive, and CNS disorders; tachykinin receptor antagonists useful in the treatment of inflammatory diseases and pain or migraine; and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.
