93040-56-3Relevant academic research and scientific papers
Ynenol Lactones: Synthesis and Investigation of Reactions Relevant to Their Inactivation of Serine Proteases
Spencer, Robin W.,Tam, Tim Fat,Thomas, Everton,Robinson, Valerie J.,Krantz, Allen
, p. 5589 - 5597 (2007/10/02)
The syntheses of ynenol lactones which are designed as serine protease suicide substrates have b
YNENOLACTONE PROTEASE INHIBITORS
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, (2008/06/13)
Compounds of the formula STR1 wherein n is 1-3; R 1, R. sup.2 and R 3 are the same or different and are hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl or aryl lower alkyl wherein when aryl is phenyl it is unsubstituted or independently substituted with one or more halo, lower alkyl or lower alkoxy groups; and R 4 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, trialkylsilyl, aryl or aryl lower alkyl wherein when aryl is phenyl it is unsubstituted or independently substituted by one or more halo, lower alkyl or lower alkoxy groups; excluding those compounds wherein R. sup.1 and R 2 are hydrogen and R 4 is ethyl, propyl or butyl. These compounds are useful as protease inhibitors.
