93040-74-5Relevant academic research and scientific papers
Synthesis of Chiral γ-Lactams via in Situ Elimination/Iridium-Catalyzed Asymmetric Hydrogenation of Racemic γ-Hydroxy γ-Lactams
Yuan, Qianjia,Liu, Delong,Zhang, Wanbin
supporting information, p. 1886 - 1889 (2017/04/11)
Chiral γ-lactams have been synthesized in excellent yields and enantioselectivities (up to 99% yield and 96% ee) from easily accessible racemic γ-hydroxy γ-lactams via an iridium-phosphoramidite catalyzed asymmetric hydrogenation. The reaction was designed based on insight into the reaction mechanism demonstrated in previous work and can be carried out at a reduced catalyst loading of 0.1 mol % on a gram scale. Several potential bioactive compounds can be synthesized from the reduced products. Mechanistic studies indicated that the reduced products were obtained via the hydrogenation of the N-acyliminium cations, generated from γ-hydroxy γ-lactams.
Sleep-Inducing N-Alkyl-5--5-hydroxy-2-pyrrolidinones and N-Alkyl-3-(trifluoromethyl)cinnamamides
Houlihan, William J.,Gogerty, John H.,Ryan, Eileen A.,Schmitt, Gemma
, p. 28 - 31 (2007/10/02)
A series of N-alkyl-3--5-hydroxy-2-pyrrolidinones and N-alkyl-3-(trifluoromethyl)-cinnamamides were prepared and screened in a series of tests designed to detect potential sleep inducers.The more active members of the series wer
