93041-20-4

Upstream product

• 2166-14-5 1,2,4,5-tetrazine-3,6-dicarboxylic acid dimethyl ester 
• 84040-16-4 C₂₁H₁₆S 
• 22979-35-7 Methyl phenyldiazoacetate 
• 922-67-8 propynoic acid methyl ester 
• 108239-14-1 4-phenyl-4,5-dihydro-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester 

Downstream Products

• 1027819-76-6 3,5-bis(hydroxymethyl)-4-phenyl-1H-pyrazole 
• 1207950-68-2 N₃,N₅-bis((S)-1-hydroxy-3-methylbutan-2-yl)-4-phenyl-1H-pyrazole-3,5-dicarboxamide 
• 1207950-66-0 N₃,N₅-bis((R)-2-hydroxy-1-phenylethyl)-4-phenyl-1H-pyrazole-3,5-dicarboxamide 

Relevant academic research and scientific papers

Novel 1,3-dipolar cycloaddition of diazocarbonyl compounds to alkynes catalyzed by InCl3 in water

The first intermolecular 1,3-dipolar cycloaddition of diazocarbonyl compounds with alkynes was developed by using an InCl3 catalyzed cycloaddition in water. The reaction was found to proceed by a domino 1,3-dipolar cycloaddition-hydrogen (alkyl or aryl) migration.

Efficient syntheses of some versatile 3,5-bifunctional pyrazole building blocks

A series of convenient synthetic procedures are reported for pyrazole derivatives with carbonyl or ester groups in the 3- and 5-positions and variable substitution pattern at C4 and at the functional side arms. All compounds have been characterized by 1H and 13C NMR spectroscopy, elemental analyses, and mass spectrometry. In addition, the structures of several pyrazole derivatives have been determined by single crystal X-ray diffraction, which provides insight into the effect of functional side arms on the hydrogen-bonded supramolecular motifs of NH-pyrazoles. Georg Thieme Verlag Stuttgart.