930451-05-1Relevant academic research and scientific papers
COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER STEM CELLS
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Page/Page column 53, (2013/03/28)
The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof: Formula (I).
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells
Germain, Andrew R.,Carmody, Leigh C.,Nag, Partha P.,Morgan, Barbara,Verplank, Lynn,Fernandez, Cristina,Donckele, Etienne,Feng, Yuxiong,Perez, Jose R.,Dandapani, Sivaraman,Palmer, Michelle,Lander, Eric S.,Gupta, Piyush B.,Schreiber, Stuart L.,Munoz, Benito
supporting information, p. 1834 - 1838 (2013/04/10)
A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE-sh-Ecad) over the isogenic control cell line (HMLE-sh-eGFP). Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations.
