930509-58-3

Upstream product

• 5202-89-1 4-chlorobenzenesulfonyl chloride 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 952443-83-3 methyl 5-chloro-2-(2-(triphenyl-λ5-phosphanyliden)-acetylamino)benzoate 
• 1247825-72-4 methyl 2-{[(3-bromophenoxy)acetyl]amino}-5-chlorobenzoate 
• 1247825-77-9 methyl 5-chloro-2-({[3-(furan-3-yl)phenoxy]acetyl}amino)benzoate 
• 1247821-40-4 5-chloro-2-({[3-(furan-3-yl)phenoxy]acetyl}amino)benzoic acid 
• 1247825-94-0 Methyl 2-{[(3-tert-butylphenoxy)acetyl]amino-}-5-chlorobenzoate 

Relevant academic research and scientific papers

Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives

Novel plasminogen activator inhibitor-1 (PAI-1) inhibitors with highly improved oral bioavailability were discovered by structure-activity relationship studies on N-acyl-5-chloroanthranilic acid derivatives. Because lipophilic N-acyl groups seemed to be important for the anthranilic acid derivatives to strongly inhibit PAI-1, synthesis of compounds in which 5-chloroanthranilic acid was bound to a variety of highly lipophilic moieties with appropriate linkers was investigated. As the result it appeared that some of the derivatives possessing aryl- or heteroaryl-substituted phenyl groups in the acyl chain had potent in vitro PAI-1 inhibitory activity. Oral absorbability of typical compounds was also evaluated in rats, and compounds 40, 55, 60 and 76 which have diverse chemical structure with each other were selected for further pharmacological evaluation.

PYRAZOLE AMIDE COMPOUND AND USE THEREOF

Disclosed is a pyrazole amide compound having fungicidal activity, with a structure shown by the general formula (I): Each of the substituents of the compound being defined as in the description. The compound of the present invention has fungicidal activity, and excellent prevention and controlling effects on diseases, such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, etc., and in particular, a better prevention and controlling effect on cucumber downy mildew and corn rust. Also disclosed is a process for preparing the compound, a fungicidal composition containing the compound of general formula(I) and the use thereof in preventing and controlling disease in crops.

AMINOPYRROLIDINE COMPOUND

Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MC4 receptor antagonistic effect.