930552-50-4Relevant academic research and scientific papers
Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ
H?ttecke, Nicole,Liebeck, Miriam,Baumann, Karlheinz,Schubenel, Robert,Winkler, Edith,Steiner, Harald,Schmidt, Boris
supporting information; experimental part, p. 2958 - 2963 (2010/08/19)
CK1 and γ-secretase are interesting targets for therapeutic intervention in the treatment of cancer and Alzheimer's disease. The CK1 inhibitor IC261 was reported to inhibit γ-secretase activity. The question is: Does CK1 inhibition directly influence γ-se
