930572-42-2Relevant articles and documents
Novel carbazole and acyl-indole antimitotics
Barta, Thomas E.,Barabasz, Amy F.,Foley, Briana E.,Geng, Lifeng,Hall, Steven E.,Hanson, Gunnar J.,Jenks, Matthew,Ma, Wei,Rice, John W.,Veal, James
scheme or table, p. 3078 - 3080 (2010/02/28)
In the course of our Heat Shock 90 program, certain carbazole compounds were identified which had an off-target antiproliferative activity. To understand the off-target activity, we studied one analog with strong activity. We discovered that it had an effect on tubulin polymerization kinetics and was competitive with colchicine. Additional analogs were made, and a number of potent compounds were identified.
