930572-44-4Relevant articles and documents
Novel carbazole and acyl-indole antimitotics
Barta, Thomas E.,Barabasz, Amy F.,Foley, Briana E.,Geng, Lifeng,Hall, Steven E.,Hanson, Gunnar J.,Jenks, Matthew,Ma, Wei,Rice, John W.,Veal, James
scheme or table, p. 3078 - 3080 (2010/02/28)
In the course of our Heat Shock 90 program, certain carbazole compounds were identified which had an off-target antiproliferative activity. To understand the off-target activity, we studied one analog with strong activity. We discovered that it had an effect on tubulin polymerization kinetics and was competitive with colchicine. Additional analogs were made, and a number of potent compounds were identified.
Carbazole derivatives
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Page/Page column 21, (2010/11/28)
Disclosed are compounds and pharmaceutically acceptable salts of Formula I: wherein n, R1, R2, R3, X, R4, R5, R6, R8, R9, and Y are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation and/or abnormal cell mitosis, such as cancer, inflammation and inflammation-associated disorders, and conditions associated with angiogenesis. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
