930593-68-3Relevant academic research and scientific papers
Synthesis of site-specifically deuterated arachidonic acid derivatives containing a remote tritium radiolabel
McGinley, Chris M.,Van Der Donk, Wilfred A.
, p. 545 - 558 (2006)
The synthesis of arachidonic acid derivatives containing site-specifically incorporated deuterium atoms and also a remote tritium label are described. Deuterium incorporation at the C11 and/or C15 position was achieved using Wittig chemistry, while the ra
The complete stereochemistry of the enzymatic dehydration of 4-hydroxybutyryl coenzyme A to crotonyl coenzyme A
Friedrich, Peter,Darley, Daniel J.,Golding, Bernard T.,Buckel, Wolfgang
, p. 3254 - 3257 (2008/12/23)
(Chemical Equation Presented) The stereospecific action of the microbial enzyme 4-hydroxybutyryl-CoA dehydratase on the three prochiral centers of its substrate 4-hydroxybutyryl-CoA can now be described as anti elimination of the 2Re and 3Si hydrogen atoms with retention of configuration during the substitution of the hydroxy group by a hydrogen atom. The results confirm the relationship of the dehydratase to acyl-CoA dehydrogenases and the view that the Fe4S4 cluster acts as a Lewis acid.
