4126-60-7

Usage

Uses

Used in Pharmaceutical Industry:
3-(Benzyloxy)propionic acid methyl ester is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs or biologically active molecules.
Used in Agrochemical Industry:
3-(Benzyloxy)propionic acid methyl ester is utilized as a precursor in the production of agrochemicals, playing a role in the synthesis of compounds that can be used in agricultural applications to protect crops and enhance yields.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-(Benzyloxy)propionic acid methyl ester is employed as a building block for drug discovery, aiding researchers in the design and synthesis of novel therapeutic agents with potential pharmacological properties.
Safety Note:
It is important to handle 3-(Benzyloxy)propionic acid methyl ester with care, as it may pose health hazards if not used properly, emphasizing the need for proper safety measures during its synthesis and application processes.

InChI:InChI=1/C11H14O3/c1-13-11(12)7-8-14-9-10-5-3-2-4-6-10/h2-6H,7-9H2,1H3

Upstream product

• 186581-53-3 diazomethane 
• 4799-68-2 3-benzyloxypropan-1-ol 
• 67-56-1 methanol 
• 6328-48-9 3-benzyloxypropionitrile 
• 100-51-6 benzyl alcohol 
• 4039-82-1 Benzyl propargyl ether 
• 1160845-83-9 C₁₁H₁₄N₂O₃ 
• 100-39-0 benzyl bromide 
• 292638-85-8 acrylic acid methyl ester 
• 865-33-8 potassium methanolate 

Downstream Products

• 106296-39-3 <(benzyloxy)methyl>ketene methyl trimethylsilyl acetal 
• 930593-68-3 3-benzyloxy[1-2H]propanal 
• 1315607-28-3 3-{2-[(phenylmethyl)oxy]ethyl}-1H-1,2,4-triazol-5-amine 
• 1315607-44-3 7-chloro-5-methyl-2-{2-[(phenylmethyl)oxy]ethyl}[1,2,4]triazolo[1,5-a]pyrimidine 
• 1315607-36-3 5-methyl-2-{2-[(phenylmethyl)oxy]ethyl}[1,2,4]triazolo[1,5-a]pyrimidin-7-ol 
• 1315607-26-1 5-methyl-2-{2-[((phenylmethyl)methyl)oxy]ethyl}-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine 
• 163812-44-0 4-benzyloxy-1-dimethylphosphinoylbutan-2-one 
• 141805-88-1 (4R)-3-<(2S,3R)-3-<(tert-Butyldimethylsilyl)oxy>-2-<(benzyloxy)methyl>butanoyl>-4-isopropyl-1,3-thiazolidine-2-thione 
• 141805-89-2 (2S,3R)-3-<(tert-Butyldimethylsilyl)oxy>-2-<(benzyloxy)methyl>-N-(4-methoxyphenyl)butylamide 
• 141805-87-0 (4R)-3-<(2S,3R)-3-Hydroxy-2-<(benzyloxy)methyl>butanoyl>-4-isopropyl-1,3-thiazolidine-2-thione 
• 141805-86-9 (4R)-3-<3-(Benzyloxy)propanoyl>-4-isopropyl-1,3-thiazolidine-2-thione 
• 119027-80-4 L-β-benzyloxypropionyl-carbobenzoxyornithine benzyl ester 
• 119027-80-4 5-Benzyloxycarbonylamino-2-(3-benzyloxy-propionylamino)-pentanoic acid benzyl ester 
• 119027-78-0 L-β-benzyloxypropionyl-dibenzylglutamate 

Relevant academic research and scientific papers

Conversion of alcohols to alkyl esters and carboxylic acids using heterogeneous palladium-based catalysts

Disclosed are methods for synthesizing an ester or a carboxylic acid from an organic alcohol. To form the ester one reacts, in the presence of oxygen gas, the alcohol with methanol or ethanol. This reaction occurs in the presence of a catalyst comprising palladium and a co-catalyst comprising bismuth, tellurium, lead, cerium, titanium, zinc and/or niobium (most preferably at least bismuth and tellurium). Alternatively that catalyst can be used to generate an acid from that alcohol, when water is also added to the reaction mix.

Aerobic oxidation of diverse primary alcohols to methyl esters with a readily accessible heterogeneous Pd/Bi/Te catalyst

Efficient aerobic oxidative methyl esterification of primary alcohols has been achieved with a heterogeneous catalyst consisting of 1 mol % Pd/charcoal (5 wt %) in combination with bismuth(III) nitrate and tellurium metal. The Bi and Te additives significantly increase the reaction rate, selectivity, and overall product yields. This readily accessible catalyst system exhibits a broad substrate scope and is effective with both activated (benzylic) and unactivated (aliphatic) alcohols bearing diverse functional groups.

Rhodium-catalyzed oxygenative addition to terminal alkynes for the synthesis of esters, amides, and carboxylic acids

A gem of a couple: The title reaction of terminal alkynes with O and Nnucleophiles proceeds in the presence of [Rh(cod)Cl}2], P(4-FC 6H4)3, and 4-picoline N-oxide. Alcohols, amines, and water add to the terminal alkynes to give esters, amides, and carboxylic acids, respectively. The reaction involves formation of a rhodium vinylidene, oxidation to a ketene by oxygen transfer, and nucleophilic addition.

Efficient three-step sequence for the deamination of α-aminoesters. Application to the synthesis of CysLT1 antagonists

A practical and efficient three-step sequence for the deamination of α-aminoesters is reported. This method is based on the NaBH4-mediated selective reduction of α-diazoesters to α-hydrazonoesters and has been successfully applied to the deamin

Pyrazole derivatives

This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

PYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS FOR HIV MEDIATED DISEASES

This invention relates to pyrazole derivatives of formula (I)or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R' to R4; ;ark defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition' of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

β-Lactams. 3. Asymmetric Total Syntheis of New Non-Natural 1β-Methylcarbapenems Exhibiting Strong Antimicrobial Activities and Stability against Human Renal Dehydropeptidase-I

Asymmetric synthesis of 11, the precursor to chiral (3R,4R)-3-ethyl>-4-acetoxyazetidin-2-one (3) was achieved by utilizing a highly diastereoselective aldol-type reaction of acetaldehyde and the chiral tin(II) enolate of 5.Similar diastereoselective alkylations of chiral and achiral tin(II) enolates 13a-d with chiral 3 were also performed to obtain the desired alkylated azetidin-2-ones (17a-d).Compounds 17a,b were successfully converted to new, non-natural 1β-methylcarbapenems 1a and 1b, which exhibited strong and wide-ranging antimicrobial activities and excellent stability against human renal dehydropeptidase-I.

PREPARATION OF β-HYDROXYPROPIONYL-GLUTAMATE AND β-HYDROXYPROPIONYL-ORNITHINE FOR STUDIES ON CLAVULANIC ACID BIOSYNTHESIS

The synthesis of β-hydroxypropionyl-glutamate and of β-hydroxypropionyl-ornithine "dipeptides" in L- and DL-configuration required for studies on the biosynthesis of clavulanic acid is described.