93065-60-2Relevant academic research and scientific papers
NMR-based investigations of acyl-functionalized piperazines concerning their conformational behavior in solution
Wodtke, Robert,Steinberg, Janine,K?ckerling, Martin,L?ser, Reik,Mamat, Constantin
, p. 40921 - 40933 (2018)
Selected N-benzoylated piperazine compounds were synthesized to study their conformational behavior using temperature-dependent 1H NMR spectroscopy. All investigated piperazines occur as conformers at room temperature resulting from the restric
Aminocarbonylations employing Mo(CO)6 and a bridged two-vial system: Allowing the use of nitro group substituted aryl iodides and aryl bromides
Nordeman, Patrik,Odell, Luke R.,Larhed, Mats
, p. 11393 - 11398 (2013/02/23)
A bridged two-vial system aminocarbonylation protocol where Mo(CO) 6 functions as an external in situ solid source of CO has been developed. For the first time both nitro group containing aryl/heteroaryl iodides and bromides gave good to excellent yields in the Mo(CO) 6-mediated and palladium(0)-catalyzed conversion to benzamides, while the identical one-vessel protocol afforded extensive reduction of the nitro functionality. The above-mentioned bridged two-compartment protocol furnished good results with both primary amines and secondary amines and sluggish aniline nucleophiles at 65-85 C reaction temperatures.
Synthesis of Disubstituted Alkanes and Piperazines as Potential Anthelmintics
Abuzar, Syed,Sharma, Satyavan
, p. 73 - 76 (2007/10/02)
A number of 1,2- and 1,3-di(4-substituted phenyl-thio/sulphono)alkanes (3-18) and 1,4-disubstituted piperazines (19-28) have been synthesized starting from 4-acetamidothiophenol (1) and piperazine, respectively.None of the compounds shows any noteworthy anthelmintic activity except 11 and 13 which eliminate 100percent of A. ceylanilum and H. nana worms from hamsters and rats respectively at a single oral dose of 250 mg/kg.
