93065-69-1Relevant articles and documents
Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits
Ulven, Trond,Receveur, Jean-Marie,Grimstrup, Marie,Rist, ?ystein,Frimurer, Thomas M.,Gerlach, Lars-Ole,Mathiesen, Jesper Mosolff,Kostenis, Evi,Uller, Lena,H?gberg, Thomas
, p. 6638 - 6641 (2007/10/03)
Hits from an in silico derived focused library for CRTH2 were transformed into highly selective antagonists with favorable ADME properties. Oral administration of 4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetic acid (19) inhibited peribronchial e