93075-09-3

Upstream product

• 93075-08-2 3-Phenyl-5-trifluoromethyl-dihydro-pyrimidine-2,4-dione 
• 381-98-6 trifluoromethyacrylic acid 
• 64-10-8 phenyl carbamate 

Relevant academic research and scientific papers

A FACILE CONVERSION OF 5-TRIFLUOROMETHYL-5,6-DIHYDROURACILS TO 5-TRIFLUOROMETHYLURACILS

5-Trifliuoromethyl-5,6-dihydrouracils were directly converted to the corresponding 5-trifluoromethyluracils by the reaction with copper(II) bromide in dimethylformamide/water or dimethylformamide/acetic acid in good to excellent yields.

Production of 5-perfluoroalkyldihydrouracil derivatives

A process for preparing a 5-perfluoroalkyl-dihydrouracil derivative of the general formula STR1 wherein Rf represents a perfluoroalkyl group, each of R1 and R2 represents a hydrogen atom, or an alkyl, cycloalkyl, aryl, aralkyl or heterocyclic group, and Y is an oxygen or sulfur atom, which comprises (a) reacting a compound of the general formula STR2 wherein X represents a halogen atom or hydroxyl group, with a urea derivative of the general formula STR3 provided that when X is a hydroxyl group and at least one of R1 and R2 is a hydrogen atom, said reaction is carried out in the presence of a condensing agent, or (b) cyclizing a compound of the general formula STR4 and a novel intermediate compound of the above formula (IV).