93076-89-2 Usage
Uses
Used in Pharmaceutical Industry:
DIACYLGLYCEROL KINASE INHIBITOR I is used as an anti-cancer agent for its ability to induce apoptosis in glioblastoma cells while avoiding apoptosis in non-cancerous cells. This selectivity makes it a highly effective anti-cancer agent and a valuable component in the development of targeted cancer therapies.
Used in Neuroprotection:
DIACYLGLYCEROL KINASE INHIBITOR I is used as a neuroprotective agent for its ability to induce autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism, potentially offering protection against neurodegenerative diseases.
Used in Metabolic Research:
DIACYLGLYCEROL KINASE INHIBITOR I is used as a research tool for studying the role of DAGK in metabolic processes, such as preventing conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes.
Used in Antiviral Research:
DIACYLGLYCEROL KINASE INHIBITOR I is used as an antiviral agent for its ability to block filovirus internalization in host cells, providing a potential avenue for the development of treatments against viral infections.
Biological Activity
Diacylglycerol (DAG) kinase inhibitor (IC 50 = 2.8 μ M); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.
References
de Chaffoy de Courcelles et al. (1985), R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet; J. Biol. Chem., 260 15762
Takita et al. (2011), Diacylglycerol kinase inhibitor R59022-induced autophagy and apoptosis in the neuronal cell line NG108-15; Arch. Biochem. Biophys., 509 197
Martinez et al. (2013), Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes; J. Lipid Res., 54 662
Stewart et al. (2019), A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells; Viruses, 11 206
Check Digit Verification of cas no
The CAS Registry Mumber 93076-89-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,0,7 and 6 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 93076-89:
(7*9)+(6*3)+(5*0)+(4*7)+(3*6)+(2*8)+(1*9)=152
152 % 10 = 2
So 93076-89-2 is a valid CAS Registry Number.
InChI:InChI=1/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
