930803-07-9Relevant academic research and scientific papers
Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A2A receptor antagonists
Shao, Yuefei,Cole, Andrew G.,Brescia, Marc-Raleigh,Qin, Lan-Ying,Duo, Jingqi,Stauffer, Tara M.,Rokosz, Laura L.,McGuinness, Brian F.,Henderson, Ian
scheme or table, p. 1399 - 1402 (2009/10/15)
A series of trisubstituted purinones was synthesized and evaluated as A2A receptor antagonists. The A2A structure-activity relationships at the three substituted positions were studied and selectivity against the A1 recept
PURINONE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES
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Page/Page column 22-23, (2008/06/13)
The invention relates to purinone derivatives useful in treating disorders that are mediated by adenosine receptor function, including neurodegenerative diseases and inflammation. The compounds are of the general formula (I). An example is formula (II).
