930806-58-9Relevant academic research and scientific papers
Bench-Stable N-Heterocyclic Carbene Nickel Precatalysts for C?C and C?N Bond-Forming Reactions
Strieth-Kalthoff, Felix,Longstreet, Ashley R.,Weber, Jessica M.,Jamison, Timothy F.
, p. 2873 - 2877 (2018/05/07)
Herein, we introduce a new class of bench-stable N-heterocyclic carbene (NHC) nickel-precatalysts for homogeneous nickel-catalysis. The nickel(II) complexes are readily activated to Ni0 in situ under mild conditions, via a proposed Heck-type me
Nitrile assisted, Bronsted acid catalyzed regio and stereoselective diarylphosphonylation of allyl silyl ethers
Ho, Chun-Yu,Chan, Chun-Wa,Wo, Siu-Kwan,Zuo, Zhong,Chan, Lai-Ying
supporting information; experimental part, p. 3480 - 3487 (2010/08/21)
We have discovered a mild, catalytic protocol for the regio- and stereoselective synthesis of trisubstituted allyl diarylphosphonates from the corresponding disubstituted allyl silyl ethers, circumventing the challenges related to the preparation and availability of stereodefined trisubstituted olefins. A closely related arylation reaction was also discovered during the methodology development. By simply switching the reaction medium, high phosphonylation/arylation ratios and vice versa can be achieved. This may not be a direct result of changing solvent polarity. The allyl diarylphosphonates were evaluated as carboxylesterase inhibitors, and the screening results revealed that the inhibitory efficiency is highly related to the choice of alkenes and aryl substituents. The Royal Society of Chemistry 2010.
Highly selective coupling of alkenes and aldehydes catalyzed by [Ni(NHC){P(OPh)3}]: Synergy between a strong σ donor and a strong π acceptor
Ho, Chun-Yu,Jamison, Timothy F.
, p. 782 - 785 (2007/10/03)
(Chemical Equation Presented) Give and take: Both a strong electron donor (1) and a strong electron acceptor (P(OPh)3) are necessary for a highly selective, nickel-catalyzed coupling reaction between alkenes, aldehydes, and silyl triflates (see
Nickel-catalyzed coupling of alkenes, aldehydes, and silyl triflates
Ng, Sze-Sze,Ho, Chun-Yu,Jamison, Timothy F.
, p. 11513 - 11528 (2007/10/03)
A full account of two recently developed nickel-catalyzed coupling reactions of alkenes, aldehydes, and silyl triflates is presented. These reactions provide either allylic alcohol or homoallylic alcohol derivatives selectively, depending on the ligand em
