93089-77-1Relevant academic research and scientific papers
Aqueous phase preparation method of 1-(2-hydroxyethyl)-4-(2-hydroxypropyl) piperazine
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Paragraph 0032; 0035-0042; 0043; 0046-0049; 0052, (2021/06/13)
The invention relates to an aqueous phase preparation method of 1-(2-hydroxyethyl)-4-(2-hydroxypropyl) piperazine, which comprises the following steps: adding a first reaction raw material piperazine into water, then adding a single-ended protective agent, then adding a second reaction raw material, then adding an extracting agent, then under a stirring condition, adjusting the pH value to 9-14, perfroming standing, and then filtering and separating to obtain an aqueous phase; transferring the water phase into a reaction kettle, sealing the reaction kettle, vacuumizing, and introducing nitrogen into the reaction kettle; and reacting to obtain the target product 1-(2-ethoxyl) 4-(2-hydroxypropyl) piperazine. Piperazine, epoxypropane and ethylene oxide are used as raw materials, and the raw materials are low in cost, easy to obtain and wide in source. The reaction is simple, operation is easy, and the target product yield is high. Meanwhile, the invention also provides a new green and economic thought for synthesizing the piperazine derivative with the asymmetric structure by taking piperazine as a raw material, and the application range of the piperazine derivative is expanded.
The study on organic nitrates, part V. New derivatives of piperazine potential NO donors
Korzycka, Lucyna
, p. 445 - 450 (2007/10/03)
We have obtained a series of non-symmetrical 1,4-disubstituted derivatives of piperazine, with the structure of organic nitrates, as potential NO donors. These compounds were obtained from respective hydroxyl derivatives of piperazine in an esterification reaction by fuming nitric acid. The obtained nitrates were tested in-vitro by reaction with a sulfhydryl compound. The structure of the most active nitrate and its hydroxyl analogue was used for the calculation of geometrical optimization with the determination of 3D-QSAR by a semi-empirical method PM3 using HyperChem 4.5.
