93098-26-1

Upstream product

• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 105-53-3 diethyl malonate 

Downstream Products

• 93098-63-6 (4S,5R)-2-Amino-6-oxo-4-(3-trifluoromethyl-phenyl)-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 129216-10-0 2,6-bis(phenylthio)-4-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxaldehyde 
• 129216-09-7 2-(ethylthio)-6-chloro-4-(3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxaldehyde 
• 129215-99-2 2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde 
• 129216-04-2 2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde 
• 129216-05-3 2,6-dichloro-4-(3-(trifluoromethyl)phenyl)pyridine-3,5-dicarboxaldehyde 
• 129216-12-2 3-(3-(trifluoromethyl)phenyl)glutaric acid 
• 129215-95-8 4-(3-(trifluoromethyl)phenyl)glutarimide 

Relevant academic research and scientific papers

Diastereoselective construction of spirocyclic pyrrolidines bearing two quaternary centers via CuII-P, N-Ligand catalyzed 1,3-dipolar cycloaddition

Here, we report a convenient access to diastereoselective synthesis of polysubstituted pyrrolidines bearing a unique spiro quaternary center at the C-2 position and another quaternary center at C-4. The synthesis system, CuII/P, N-Ligand-cataly

Unnatural α-amino ethyl esters from diethyl malonate or ethyl β-bromo-α-hydroxyiminocarboxylate

We have explored here the scope of the age-old diethyl malonate-based accesses to α-amino esters involving Knoevenagel condensations of diethyl malonate on aldehydes, reductions of the resulting alkylidenemalonates, the preparation of the corresponding α-hydroxyimino esters and their final reduction. This synthetic pathway turned out to be general although some unexpected limitations were encountered. The synthetic modifications of some of the intermediates - using Suzuki-Miyaura coupling or cycloadditions - before undertaking the oximation step - provided accesses to further α-amino esters. Moreover, other pathways to α-hydroxyimino esters were explored including an attempt to improve the cycloadditions between ethyl β-bromo-α-hydroxyiminocarboxylate and various alkylfuranes.

SUBSTITUTED PYRAZOLIDINONE DERIVATIVE AND METHOD FOR USE THEREOF

PROBLEM TO BE SOLVED: To provide a herbicide showing sufficient safety on important crops and a compound useful for it. SOLUTION: The present invention provides a herbicide for agricultural and horticultural use containing a pyrazolidinone derivative repr

ARYL SUBSTITUTED BICYCLIC COMPOUNDS AS HERBICIDES

Disclosed are compounds of Formula 1, including all N oxides, stereoisomers, and salts thereof, wherein Q1, Q2, R1, R2, Y, J and R7 are as defined in the disclosure. Also disclosed are compositions co

Chiral-Zn(NTf2)2-complex-catalyzed diastereo- and enantioselective direct conjugate addition of arylacetonitriles to alkylidene malonates

Chiral N,N′-dioxide/Zn(NTf2)2 complexes were demonstrated to be highly effective in the direct asymmetric conjugate addition of arylacetonitriles to alkylidene malonates under mild conditions. A wide range of substrates were tolerated to afford their corresponding products in moderate-to-good yields with high diastereoselectivities (82:18->99:1 d.r.) and enantioselectivities (81-99 % ee). The reactions performed well, owing to the high Lewis acidity of the metal triflimidate and a ligand-acceleration effect. The N,N′-dioxide also benefited the deprotonation process as a Bronsted base. The catalytic reaction could be performed on the gram-scale with retention of yield, diastereoselectivity, and enantioselectivity. The products that contained functional groups were ready for further manipulation. In addition, a possible catalytic model was proposed to explain the origin of the asymmetric induction. Copyright