93103-82-3Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF
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, (2017/07/15)
The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.
MODULATORS FOR NICOTINIC ACETYLCHOLINE RECEPTOR α2 AND α4 SUBUNITS
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Page/Page column 37; 38, (2016/12/22)
Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChR) are important therapeutic candidates as well as valuable research tools. We identified a novel type II PAM, (R)-7-bromo-N-(piperidin-3-yl)benzo[b]thiophene-2-carboxamide (B
Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex
Urwyler, Stephan,Floersheim, Philipp,Roy, Bernard L.,Koller, Manuel
supporting information; experimental part, p. 5093 - 5107 (2010/03/02)
Retaining agonistic activity at the glycine coagonist site of the NMDA receptor in molecules derived from glycine or D-serine has proven to be difficult because in the vicinity of the α-amino acid group little substitution is tolerated. We have solved thi
Condensed Heterocyclics: Part XVI - Synthesis of N-Substituted 4-Bromo-2-guanidinomethylbenzothiophenes
Sharma, K. S.,Lata, Suman
, p. 38 - 41 (2007/10/02)
4-Bromo-2-chloromethylbenzothiophene (V) and 4-bromobenzothiophene-2-carboxamides (VII, XI) have been converted into 2-aminomethyl- and 2-(N-methyl)aminomethyl-benzothiophenes (VIII, XII).The amine (VIII) has been transformed into N-substituted 2-guanidinomethylbenzothiophenes (IX) by reaction with appropriate N-substituted S-methylisothioureas.
