93108-13-5Relevant academic research and scientific papers
Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia
Suthiwong, Jittra,Wandee, Jaroon,Pitchuanchom, Siripit,Sojikul, Punchapat,Kukongviriyapan, Veerapol,Yenjai, Chavi
, p. 2042 - 2049 (2018/07/21)
Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC50 ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC50 values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents.
Synthesis and biological activity of bromolignans and cyclolignans
San Feliciano,Medarde,Pelaez Lamamie De Clairac,Lopez,Puebla,Gravalos,Lazaro,De Quesada
, p. 421 - 426 (2007/10/02)
Nine lignan derivatives (4-12) have been obtained from (-)-yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P-388, A-549, HT-29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows antiviral (HSV-1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.
Studies on the Constituents of the Seeds of Hernandia ovigera L. IV. Syntheses of β-Peltatin-A and -B Methyl Ethers from Desoxypodophyllotoxin
Yamaguchi, Hideo,Nakajima, Syunji,Arimoto, Masao,Tanoguchi, Mariko,Ishida, Toshimasa,Inoue, Masatoshi
, p. 1754 - 1760 (2007/10/02)
Two kinds of 4-aryltetralin type lignans, β-peltatin-A methyl ether (I-A) and β-peltatin-B methyl ether (I-B), were synthesized from desoxypodophyllotoxin (DPT), which is available in large quantities from the seeds of Hernandia ovigera L. (Hernandiaceae).The syntheses were achieved via demethylene-DPT (IV), 8-bromo-demethylene-DPT (V) and 8-bromo-DPT (VI).Methylenation of V was carried out successfully by using cesium fluoride and methylene iodide in DMF.Compound I-B was readily obtained by the reaction of VI with cuprous iodide and sodium methoxide in the presence of pyridine.Synthesis of I-A was only achieved by the reaction of lithiated VI with nitrobenzene at -100 deg C in the presence of tetramethylethylene diamine, and I-A was obtained in low yield, together with I-B.Keywords Hernandia ovigera; 4-aryltetralin lignan; desoxypodophyllotoxin (DPT); desoxypicropodophyllin (DPP); 2'-bromo-desoxypodophyllotoxin; 8-bromo-desoxypodophyllotoxin; beta-peltatin-A methyl ether; beta-peltatin-B methyl ether; lithiated desoxypodophyllotoxin; lignan X-ray analysis
