93151-61-2Relevant academic research and scientific papers
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor
Newman, Amy Hauck,Beuming, Thijs,Banala, Ashwini K.,Donthamsetti, Prashant,Pongetti, Katherine,Labounty, Alex,Levy, Benjamin,Cao, Jianjing,Michino, Mayako,Luedtke, Robert R.,Javitch, Jonathan A.,Shi, Lei
experimental part, p. 6689 - 6699 (2012/09/25)
The dopamine D3 receptor (D3R) has been implicated in substance abuse and other neuropsychiatric disorders. The high sequence homology between the D3R and D2R, especially within the orthosteric binding site (OBS) that binds dopamine, has made the developm
Structure-Activity Relationship Studies of Central Nervous System Agents. 13. 4--1-(2-methoyphenyl)piperazine, a new Putative 5HT1A Receptor Antagonist, and Its Analogs
Mokrosz, Jerzy L.,Paluchowska, Maria H.,Chojnacka-Wojcik, Ewa,Filip, Malgorzata,Charakchieva-Minol, Sijka,et al.
, p. 2754 - 2760 (2007/10/02)
A new set of 4-alkyl-1-(o-methoxyphenyl)piperazines containing a terminal benzotriazole fragment were synthesized, and their 5-HT1A and 5-HT2 affinity was determined.It was shown that the benzotriazole moiety contributes to both the
