93156-92-4

Upstream product

• 1421-49-4 3,5-Di-tert-butyl-4-hydroxybenzoic acid 
• 74-88-4 methyl iodide 
• 1518-53-2 1,3-di-tert-butyl-2-methoxy-5-methylbenzene 
• 115126-97-1 methyl 3,5-di-t-butyl-4-methoxybenzoate 

Downstream Products

• 94430-24-7 3,5-Bis(1,1-dimethylethyl)-4-(methoxy)-benzamide 

Relevant academic research and scientific papers

Design and synthesis of photodissociable ligands based on azoimidazoles for light-driven coordination-induced spin state switching in homogeneous solution

Light-switchable azoimidazoles were rationally designed and synthesized, and their performance was investigated as photodissociable ligands (PDL) and for spin state switching of Ni porphyrins. The rationally designed ligands exhibit a high photochemical conversion rate (trans a? cis > 98%) and no measurable fatigue over a large number of switching cycles at room temperature under air. As compared to the known phenylazopyridines, the phenylazoimidazoles exhibit a much stronger affinity as axial ligands to Ni porphyrin in the binding trans configuration and a low affinity in their cis form. This affinity switching was used to control the coordination number of Ni2+. Concomitant with the change in coordination number is the change of the spin state from triplet (high spin) to singlet state (low spin). We report on phenylazoimidazole-based PDLs that switch the paramagnetic ratio of the investigated nickel species by up to 70%. Consequently, azoimidazoles exhibit considerably higher switching efficiencies than previously described pyridine-based PDLs.

Easier preparation of 2,6-Di-tert-butylphenyl derivatives 1

Despite steric shielding by the 2,6-di-tert-butylphenyl group (super-2,6-xylyl=xyl*), inexpensive sodium phenolate (xyl*-ONa) reacts with dimethyl sulfate to produce only xyl*-OCH3 (94%) with complete suppression of the alternative 4-methylation. Reductive cleavage of xyl*-OCH3 by elemental lithium with the help of an electron carrier generates xyl*-Li, which in turn yields xyl*-CO2H (63%). The corresponding 4-methyl-derivatives of these compounds were obtained analogously. The acid chloride xyl*-COCl (77% yield) acylates HalMgCH 2R to give only xyl*-COCH3 (86%) or xyl*-COEt (97%). These two ketones react with n-butyllithium (no carbonyl addition) and Cl-PO(OEt)2 to furnish only the enol phosphates xyl*-C(=CH 2)OPO(OEt)2 (84%) or xyl*-C(=CHCH 3)OPO(OEt)2 (up to 70%), respectively. Only 1,2-elimination occurs when the latter two products are treated with tert-butyllithium, affording xyl*-CCH (68%) or xyl*-CCMe (88%), respectively. Georg Thieme Verlag Stuttgart - New York.

CYCLYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed. Specifically, a series of compounds of substituted or unsubstituted cyclylamine derivatives as shown in formulas (1).

Calcium channel inhibitors comprising benzhydril spaced from piperazine

Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.

Calcium channel inhibitors comprising benzhydril spaced from piperazine

Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.

Calcium channel inhibitors comprising benzhydril spaced from piperazine

Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.