1518-53-2

Usage

Uses

Used in Food Industry:
3,5-di-tert-butyl-4-methoxytoluene is used as a preservative in the food industry to prevent spoilage and rancidity of fats and oils, ensuring the freshness and quality of various food products.
Used in Personal Care Products:
In the personal care industry, 3,5-di-tert-butyl-4-methoxytoluene is used as an antioxidant to prevent the degradation of ingredients, such as oils and fats, that are commonly found in cosmetics and skincare products.
Used in Pharmaceutical Industry:
3,5-di-tert-butyl-4-methoxytoluene is used as a stabilizer in pharmaceuticals to prevent the oxidation of sensitive ingredients, ensuring the efficacy and safety of medications.
Used in Industrial Materials and Fuels:
In the industrial sector, 3,5-di-tert-butyl-4-methoxytoluene is used as a chemical stabilizer to prevent the oxidation and degradation of materials and fuels, enhancing their performance and durability.

InChI:InChI=1/C16H26O/c1-11-9-12(15(2,3)4)14(17-8)13(10-11)16(5,6)7/h9-10H,1-8H3

Upstream product

• 128-37-0 2,6-di-tert-butyl-4-methyl-phenol 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 110-05-4 di-tert-butyl peroxide 
• 22731-83-5 S,S-diphenylsulphoximine 

Downstream Products

• 93629-15-3 5-(bromomethyl)-1,3-di-tert-butyl-2-methoxybenzene 
• 128-37-0 2,6-di-tert-butyl-4-methyl-phenol 
• 1242280-18-7 2,6-di-tert-butyl-4-methylbenzoic acid 
• 15181-11-0 3, 5-di-tert-butyltoluene 
• 93156-92-4 3,5-Bis(1,1-dimethylethyl)-4-methoxy-benzoic acid 
• 42031-71-0 lithium 2,6-di-tert-butyl-4-methylphenoxide 
• 1262766-27-7 C₁₆H₂₄Br₂O 
• 1016636-85-3 diethyl (3,5-di-tert-butyl-4-methoxybenzyl)phosphonate 

Relevant academic research and scientific papers

Amphipathic compound containing hindered phenol and phosphite, synthetic method and application thereof

The invention relates to an amphipathic compound which is composed of a hindered phenol unit, a phosphite unit, a crown ether unit and a straight-chain segment unit. The synergistic effect is controlled by controlling the length of the straight-chain segm

Amphipathic compound containing hindered phenol and pentaerythritol phosphite, synthetic method and application thereof

An amphipathic compound containing both anti-static and anti-oxidizing functional groups is composed of a hindered phenol unit, a pentaerythritol phosphite unit, a crown ether unit and a straight-chain segment unit. The synergistic effect is controlled by controlling the length of the straight-chain segment unit to regulate the distance from the hindered phenol to the pentaerythritol phosphite units, and meanwhile, the content of effective functional groups in unit mass of the compound and the compatibility between the compound and resin are also controlled. Through migration of the crown ether group, the hindered phenol unit and the phosphite unit are migrated to the surface of the resin, so that oxidization in air can be eliminated more effectively. Because the hindered phenol unit and the pentaerythritol phosphite unit have large space structures, so that the crown ether structure is prevented from falling off from the surface of the resin, thereby increasing anti-static time of the compound. The compound can be used as an anti-static and anti-oxidizing agent for polypropylene or polyethylene.

A double-functional group comprising the anti-oxidant compound and its synthetic method

The invention relates to a bifunctional group-containing antioxidant compound, which comprises a hindered phenol unit, a phosphite unit and a straight chain segment unit. According to the present invention, a length of the straight chain segment unit is c

Copper-catalyzed N-methylation/ethylation of sulfoximines

A protocol for the copper-catalyzed N-methylation of sulfoximines with di-tert-butyl peroxide (DTBP) was developed. This protocol has good functional group tolerance leading to N-methylated sulfoximines in moderate to good yields. Besides, N-ethylation of sulfoximines was achieved in the presence of bis(1,1-dimethylpropyl)peroxide as the ethylating agent under a standard procedure.

Microwave mediated protection of hindered phenols and alcohols

Hindered phenols and alcohols were protected as their corresponding ethers using different alkylating agents in presence of KOH/DMSO under microwave irradiation.

New hydroxystilbenoid derivatives endowed with neuroprotective activity and devoid of interference with estrogen and aryl hydrocarbon receptor-mediated transcription

We have synthesized a series of new (E) stilbenoid derivatives containing hydroxy groups at ring positions identical or similar to those of trans-resveratrol and bearing one or two bulky electron donating groups ortho to 4′-OH and we have evaluated their neuroprotective activity using glutamate-challenged HT22 hippocampal neurons to model oxidative stress-induced neuronal cell death. The most active derivatives, 5-{(E)-2-[3,5-bis(1- ethylpropyl)-4-hydroxyphenyl]ethenyl}-1,3-benzenediol (2), 5-[(E)-2-(3,5-di- tert-butyl-4-hydroxyphenylethenyl)]-1,3-benzenediol (4) and 5-{(1E,3E)-4-[3,5- bis(1-ethylpropyl)-4-hydroxyphenyl]-1,3-butadienyl}-1,3-benzenediol (6), had EC50 values of 30, 45 and 12 nM, respectively, and were ca. 100 to 400-fold more potent than resveratrol. Derivatives 2, 4 and 6 lacked cytotoxic activity against HT22 cells and estrogen receptor agonist or antagonist activity in estrogen response element-dependent gene expression and in estrogen-dependent proliferation of MCF-7 human breast cancer cells. In addition, they were incapable of interfering with aryl hydrocarbon receptor-mediated xenobiotic response element-dependent gene expression. Derivatives 2, 4 and 6 might assist in the development of lead candidates against oxidative stress-driven neurodegenerative diseases that will not increase endocrine cancer risk nor affect drug activation and detoxification mechanisms.

Easier preparation of 2,6-Di-tert-butylphenyl derivatives 1

Despite steric shielding by the 2,6-di-tert-butylphenyl group (super-2,6-xylyl=xyl*), inexpensive sodium phenolate (xyl*-ONa) reacts with dimethyl sulfate to produce only xyl*-OCH3 (94%) with complete suppression of the alternative 4-methylation. Reductive cleavage of xyl*-OCH3 by elemental lithium with the help of an electron carrier generates xyl*-Li, which in turn yields xyl*-CO2H (63%). The corresponding 4-methyl-derivatives of these compounds were obtained analogously. The acid chloride xyl*-COCl (77% yield) acylates HalMgCH 2R to give only xyl*-COCH3 (86%) or xyl*-COEt (97%). These two ketones react with n-butyllithium (no carbonyl addition) and Cl-PO(OEt)2 to furnish only the enol phosphates xyl*-C(=CH 2)OPO(OEt)2 (84%) or xyl*-C(=CHCH 3)OPO(OEt)2 (up to 70%), respectively. Only 1,2-elimination occurs when the latter two products are treated with tert-butyllithium, affording xyl*-CCH (68%) or xyl*-CCMe (88%), respectively. Georg Thieme Verlag Stuttgart - New York.

BENZYLIDENE RHODANINES

This invention provides novel benzylidene rhodanines which are useful as agents in treating or preventing conditions associated with . beta.-amyloid peptide. This invention further provides methods of treating or preventing Alzheimer's Disease which comprises administering to a mammal in need thereof an effective amount of one or more of the benzylidene rhodanines of the present invention.