932-82-1

Basic information

• Product Name: 4,5-DIBROMO-1H-PYRROLE-2-CARBOXALDEHYDE
• Synonyms: 4,5-DIBROMO-1H-PYRROLE-2-CARBOXALDEHYDE;4,5-Dibromo-1H-pyrrole-2-carboxaldehyde 97%;4,5-DibroMo-1H-pyrrole-2-carbaldehyde;4,5-Dibromo-1H-pyrrole-2-carboxaldehyde97%
• CAS NO: 932-82-1
• Molecular Formula: C₅H₃Br₂NO
• Molecular Weight: 252.89
• Product Categories: Azoles;blocks;Bromides;Carboxes
• Mol File: 932-82-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 144-148
• Boiling Point: 341.9 °C at 760 mmHg
• Flash Point: 160.6 °C
• Appearance: /
• Density: 2.262 g/cm³
• Vapor Pressure: 7.78E-05mmHg at 25°C
• Refractive Index: 1.691
• CAS DataBase Reference: 4,5-DIBROMO-1H-PYRROLE-2-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIBROMO-1H-PYRROLE-2-CARBOXALDEHYDE(932-82-1)
• EPA Substance Registry System: 4,5-DIBROMO-1H-PYRROLE-2-CARBOXALDEHYDE(932-82-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 932-82-1(Hazardous Substances Data)

Usage

General Description

4,5-DIBROMO-1H-PYRROLE-2-CARBOXALDEHYDE is a chemical compound with the molecular formula C6H4Br2NO. It is a yellow crystalline solid with a molecular weight of 260.912 g/mol. 4,5-DIBROMO-1H-PYRROLE-2-CARBOXALDEHYDE is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. It is also used as a reagent in organic chemistry reactions. 4,5-DIBROMO-1H-PYRROLE-2-CARBOXALDEHYDE has a range of applications in medicinal chemistry, biochemistry, and other fields, making it an important and versatile chemical compound in the chemical industry.

InChI:InChI=1/C5H3Br2NO/c6-4-1-3(2-9)8-5(4)7/h1-2,8H

Upstream product

• 1003-29-8 2-pyrrole aldehyde 

Downstream Products

• 1452507-31-1 2-hydroxy-4,5-bis(4-hydroxyphenyl)-2-isobutyl-1H-pyrrol-3(2H)-one 
• 53164-84-4 4,5-bis(4-methoxyphenyl)-1H-pyrrole-2-carbaldehyde 
• 30011-17-7 5-isobutyl-2,3-bis(4-methoxyphenyl)-1H-pyrrole 

Relevant articles and documents

Regioselective dicouplings: Application to differentially substituted pyrroles

In an effort to develop a more concise route to differentially substituted pyrroles (such as that found in the lamellarins), a completely regioselective one-pot double Suzuki coupling has been discovered. The key feature is the use of a ligand-free pallad

Design, Sustainable Synthesis, and Programmed Reactions of Templated N-Heteroaryl-Fused Vinyl Sultams

A de novo design and synthesis of N-heteroaryl-fused vinyl sultams as templates for programming chemical reactions on vinyl sultam periphery or (hetero)aryl ring is described. The key features include rational designing and sustainable synthesis of the template, customized reactions of vinyl sultams at C=C bond or involving N-S bond cleavage, and reactions on the periphery of the heteroaryl ring for late-stage diversification. The simple, easy access to the template coupled with opportunities for the synthesis of diversely functionalized heterocyles from a single template constitutes a rare study in contemporary organic synthesis.

Synthesis and evaluation of novel marine bromopyrrole alkaloid-based hybrids as anticancer agents

A series of twenty three novel hybrids of marine bromopyrrole alkaloids with chalcone, isoxazole and flavone structural features were synthesized and evaluated for in vitro anticancer activity by MTT assay against five human cancer cell lines. Among the synthesized chalcones, hybrids 4a and 4h (IC50 range: 0.18 μM-12.00 μM) showed anticancer activity against all the tested cancer cell lines. Promising cytotoxic activities were exhibited by flavones derivatives, 5a and 5b (0.41 μM-1.28 μM) against cell lines PA1 and KB403. Isoxazole hybrids, 6b-6e selectively inhibited oral and mouth cancer cell line KB403, among which 6c (IC50 = 2.45 μM) was found to be most active.