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• 35975-00-9 5-amino-6-nitroquinoline 
• 42143-23-7 5,6-diaminoquinoline 
• 100672-32-0 5-amino-6-(4-methoxybenzylidene)quinoline 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 100-09-4 4-methoxybenzoic acid 

Relevant academic research and scientific papers

A versatile method for the synthesis of benzimidazoles from o-nitroanilines and aldehydes in one step via a reductive cyclization

A highly efficient and versatile method for the synthesis of benzimidazoles was achieved in one step via the Na2S2O4 reduction of o-nitroanilines in the presence of aldehydes. Heating a solution of o-nitroaniline (Ic) and an aldehyde in EtOH or another appropriate solvent, in the presence of aqueous or solid Na2S2O4, provided facile access to a series of 2-substituted N-H benzimidazoles 5a-m containing a wide range of functional groups not always compatible with the existing synthetic methods. This methodology has also been applied to the regioselective synthesis of N-alkyl and N-aryl benzimidazoles 6a-f via the cyclization of the corresponding N-substituted nitroanilines 13a-e, respectively. In addition, the method was applied successfully to the synthesis of other imidazole containing heterocyclic ring systems such as 1H-imidazo[4,5-b]pyridines 14a,b and 1H-imidazo[4,5-f]quinoline 15.

Studies on the Formation of Imidazoquinolines from Quinoline-5,6-diamine and Aromatic Aldehydes

Condensation of quinoline-5,6-diamine (I) with aromatic aldehydes in acetic acid yields 3H-3-arylmethyl-2-imidazoquinolines (II) and 2-aryl-1H-imidazoquinolines (III).The formation of these compounds has been explained through the intermedia

A Facile Synthesis of 2-Substituted Imidazoquinolines

Condensation of quinoline-5,6-diamine (II) with aliphatic and aromatic acids under catalytic and thermal conditions results in the corresponding 2-alkyl/aryl-1H-imidazoquinolines (I).