932015-07-1Relevant academic research and scientific papers
Synthesis of β-(1→6)-linked glucosamine oligosaccharides corresponding to fragments of the bacterial surface polysaccharide poly-N-acetylglucosamine
Gening, Marina L.,Tsvetkov, Yury E.,Pier, Gerald B.,Nifantiev, Nikolay E.
, p. 567 - 575 (2007)
A series of 3-β-acetamidopropyl oligo-β-(1→6)-glucosamines consisting of 5, 7, 9 and 11 glucosamine residues, and a series of corresponding per-N-acetylated derivatives were synthesized using a convergent blockwise approach. These compounds represent frag
Synthesis of five nona-β-(1→6)-d-glucosamines with various patterns of N-acetylation corresponding to the fragments of exopolysaccharide of Staphylococcus aureus
Yudina, Olga N.,Gening, Marina L.,Tsvetkov, Yury E.,Grachev, Alexey A.,Pier, Gerald B.,Nifantiev, Nikolay E.
, p. 905 - 913 (2011/06/20)
A series of five 3-acetamidopropyl β-glycosides of nona-β-(1→6)-glucosamines containing two N-acetylglucosamine residues separated by a different number of glucosamine units with free amino groups have been synthesized using a convergent blockwise approac
The study of the reaction of terminated oligomerization in the synthesis of oligo-(β1-6)-glucosamines
Gening,Tsvetkov,Pier,Nifantiev
, p. 389 - 399 (2008/02/09)
The applicability of terminated oligomerization to the synthesis of oligo-(β1-6)-glucosamines, fragments of the intercellular polysaccharide adhesin of staphylococci, was studied. The reactions of terminated oligomerization were carried out with mono-, di-, and trisaccharide monomers and N-protected aminopropanol; and spacered mono-and disaccharides as terminating molecules were also attempted. The primary formation of cyclic products of monomer intramolecular glycosylation was observed in almost all the reactions. Only the experiments with the monomer based on the disaccharide bromide under the conditions of the Helferich reaction led to reduced yields (30%) of the cyclic products. However, even in this case, the desired terminated oligosaccharides were generated in approximately 10% yield and mainly were the products of single glycosylation of the terminator by the monomer. These experiments allow the conclusion that, under the examined conditions, the reaction of terminated oligomerization could not result in the synthesis of oligoglucosamines with a high molecular mass. Pleiades Publishing, Inc., 2006.
