932017-89-5

Upstream product

• 932017-91-9 (3E,5E)-6-(3-(adamantan-1-yl)-4-benzyloxyphenyl)-3-(ethoxycarbonyl)hexa-3,5-dienoic acid 
• 768-95-6 1-adamanthanol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 100-44-7 benzyl chloride 
• 932017-93-1 ethyl (E)-3-(3-(adamantan-1-yl)-4-benzyloxyphenyl)acrylate 
• 932017-94-2 (E)-3-(3-(adamantan-1-yl)-4-benzyloxyphenyl)prop-2-en-1-ol 
• 932017-95-3 (E)-3-(3-(adamantan-1-yl)-4-benzyloxyphenyl)acrylaldehyde 
• 932017-92-0 3-(adamantan-1-yl)-4-(benzyloxy)benzaldehyde 
• 352647-05-3 3-(adamantan-1-yl)-4-hydroxybenzaldehyde 

Relevant academic research and scientific papers

New synthetic approach to atypical retinoids: application of a versatile annulation procedure

A new approach to an atypical retinoid is presented. The C15 skeleton was built up by exploiting a step-by-step sequence: the C9 fragment of an intermediate was homologated by reaction with a C4 phosphorane, and then submitted to a benzannulation reaction. The last two carbon atoms were inserted by a Wittig reaction with the C2 phosphorane of ethyl bromoacetate. Manipulation of functional groups was then performed.