932027-66-2

Basic information

• Product Name: 6-phenylindolo[2,1-a]isoquinoline
• Synonyms: 6-phenylindolo[2,1-a]isoquinoline
• CAS NO: 932027-66-2
• Molecular Weight: 293.368
• Mol File: 932027-66-2.mol

Chemical Properties

• CAS DataBase Reference: 6-phenylindolo[2,1-a]isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenylindolo[2,1-a]isoquinoline(932027-66-2)
• EPA Substance Registry System: 6-phenylindolo[2,1-a]isoquinoline(932027-66-2)

Safety Data

• Hazardous Substances Data: 932027-66-2(Hazardous Substances Data)

Upstream product

• 948-65-2 2-phenyl-indole 
• 103-63-9 1-phenyl-2-bromoethane 
• 88207-45-8 2-(2'-bromophenyl)-1H-indole 
• 120-46-7 1,3-diphenylpropanedione 
• 120-72-9 indole 
• 109744-41-4 1-iodo-2-(2-phenylethynyl)benzene 
• 21375-88-2 1-bromo-2-(phenylethenyl)benzene 

Relevant articles and documents

Synthesis of Indolo[2,1- a ]isoquinolines via Copper-Catalyzed C-C Coupling and Cyclization of 2-(2-Bromoaryl)-1 H -indoles with 1,3-Diketones

2-(2-Bromoaryl)-1 H -indoles are coupled and cyclized with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of copper(I) iodide along with a base to afford the corresponding indolo[2,1- a ]isoquinolines in moderate to good yields.

A synthetic method of 6-phenylindolo[2,1-a]isoquinoline compounds

A synthetic method of 6-phenylindolo[2,1-a]isoquinoline compounds is disclosed. According to the method, alkyne bromide and an indole compound are adopted as raw materials, palladium is adopted as a catalyst, a base is adopted as a promoter, a ligand is added, an organic solvent is adopted as a solvent, the temperature is raised to 80-130 DEG C under inert gas protection, a reaction is performed under stirring for 12-24 h, the reaction product is cooled to room temperature after the reaction is finished, and is subjected to vacuum distillation concentration to obtain a crude product, and the crude product is purified through column chromatography to obtain one of the 6-phenylindolo[2,1-a]isoquinoline compounds. The method is safe and simple to operate, the raw materials are easily available and cheap, functional group tolerance is good, substrate adaptability is wide, and the method is environmentally friendly and beneficial to industrial production and is widely applied in medicines and organic synthesis.

A copper-catalyzed tandem synthesis of indolo- and pyrrolo[2,1-a] isoquinolines

(Chemical Equation Presented) Isoquinoline ring the changes: A novel strategy for the title reaction involves ortho-haloarylalkynes which undergo sequential intermolecular addition of N heterocycles onto alkynes and subsequent intramolecular ring closure by arylation. The process involves the use of hydroxymethyl benzotriazole as an efficient and inexpensive ligand for the C - N and C - C coupling reactions.