21375-88-2Relevant academic research and scientific papers
Incorporation of Palladium Catalyst Inside Cross-Linked Chitosan Hybrid Nanofibers for the Sonogashira Reaction
Zhong, S.
, p. 480 - 485 (2020)
Abstract: Nanofibers are attractive supporting matrices for catalytically active metallic catalysts. Herein, palladium species were successfully incorporated into the modified chitosan/poly(ethylene oxide)/maleic acid nanofibers by electrospinning. Then,
Facile one-pot synthesis of diarylacetylenes from arylaldehydes: Via an addition-double elimination process
Chen, Jianyang,Zhang, Xuan,Wu, Jiajun,Wang, Rui,Lei, Chunlin,An, Yanan
, p. 4701 - 4705 (2021/06/11)
A practical one-pot protocol has been developed to synthesize diarylacetylenes from arylaldehydes by treatment with 1-(arylmethyl)benzotriazoles and LiN(SiMe3)2. The reaction proceeded through imine formation, Mannich-type addition and double elimination to deliver products in up to 99% yields with broad substrate scope. In addition, gram-scale synthesis of 1-bromo-4-(phenylethynyl)benzene has been demonstrated.
Simple and efficient diaryl alkyne synthesis method
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Paragraph 0026; 0029-0031, (2021/04/14)
The embodiment of the invention discloses a simple and efficient diaryl alkyne synthesis method. The method comprises the steps of by taking arylmethylbenzotriazole and aromatic aldehyde as raw materials, carrying out addition and double-beta-elimination reaction under the action of bis (trimethylsilyl) amino salt MN (SiMe3) 2 to synthesize diaryl alkyne by a one-pot method. The raw materials and chemical reagents used in the method are easy to obtain, the reaction conditions are mild, the operation is simple, the substrate universality is good, the product yield is high, and the method is a simple and efficient diaryl alkyne synthesis method.
Alumina-Mediated π-Activation of Alkynes
Akhmetov, Vladimir,Amsharov, Konstantin,Feofanov, Mikhail,Sharapa, Dmitry I.
supporting information, p. 15420 - 15426 (2021/09/30)
The ability to induce powerful atom-economic transformation of alkynes is the key feature of carbophilic π-Lewis acids such as gold- and platinum-based catalysts. The unique catalytic activity of these compounds in electrophilic activations of alkynes is explained through relativistic effects, enabling efficient orbital overlapping with π-systems. For this reason, it is believed that noble metals are indispensable components in the catalysis of such reactions. In this study, we report that thermally activated γ-Al2O3activates enynes, diynes, and arene-ynes in a manner enabling reactions that were typically assigned to the softest π-Lewis acids, while some were known to be triggered exclusively by gold catalysts. We demonstrate the scope of these transformations and suggest a qualitative explanation of this phenomenon based on the Dewar-Chatt-Duncanson model confirmed by density functional theory calculations.
Diaryl acetylene compound containing methylene quinone as well as preparation method and application of diaryl acetylene compound
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Paragraph 0011; 0017; 0040-0042; 0061-0063, (2021/06/09)
The invention discloses a diaryl acetylene compound containing methylene quinone as well as a preparation method and application thereof, and belongs to the technical field of pharmacy and chemical industry. The structural formula of the diarylacetylene c
Metal-Free Aminoiodination of Alkynes Under Visible Light Irradiation for the Construction of a Nitrogen-Containing Eight-Membered Ring System
Kanyiva, Kyalo Stephen,Marina, Tane,Nishibe, Shun,Shibata, Takanori
supporting information, p. 2746 - 2751 (2021/04/05)
A method for the synthesis of dihydrodibenzo[c,e]azocine derivatives via a regioselective intramolecular aminoiodination of alkynes under visible light irradiation has been developed. This protocol uses a combination of iodine and hypervalent iodine to re
Gold-Catalyzed Cascade and Divergent Synthesis of Indolobenzazepines and Indoloquinolines from Nitrogen-Tethered 1,8-Diynes
Ito, Mamoru,Onoda, Hideaki,Shibata, Takanori,Takaki, Asahi
supporting information, (2022/01/22)
We describe the divergent construction of two nitrogen-containing polycyclic systems by gold-catalyzed cycloisomerizations. The gold-catalyzed cascade hydroamination and 7-endo-dig-selective cycloisomerization of nitrogen-tethered 1,8-diynes yielded indol
Sequential Addition of Amines to Nitrile and Carbon-Carbon Multiple Bond: A Route to 7-Amino-5 H-dibenzo[ c,e]azepines
Hu, Kun,Liu, Ruiting,Zhou, Xigeng
supporting information, p. 6946 - 6950 (2021/09/11)
A rare earth metal-catalyzed sequential inter- and intramolecular C-N bond formation of 2-nitrile-2′-alkenyl(alkynyl)biphenyls with amines has been developed, which provides a straightforward and efficient access to a range of new functional dibenzo[c,e]azepines. This represents the first examples of direct construction of seven-membered azaheterocycle from unsaturated nitriles and amines. Such transformations have the advantages of avoiding the use of additives, easily available starting materials, step- and high atom-economy, mild reaction conditions, and high selectivity.
2 -amino dibenzo [c, e] azepine compound and synthesis method thereof
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Page/Page column 11, (2021/09/15)
The invention belongs to the technical field of organic chemistry, and particularly relates 2 - amine dibenzo [!c, eAzepine compound and a method for synthesizing the same. The method comprises the following steps: in an organic solvent in an inert gas atmosphere and a rare earth catalyst, continuous addition/cyclization reaction of 2 -nitrile -6 - alkynyl biphenyl with an amine to obtain 2 -aminobenzo [!c, eAzepine compound. A core structural unit - of the compound of the present invention is dibenzo [!c, eAzepine is widely found in the synthesis of biologically active molecules and natural products. The synthesis method is novel, has the advantages of mild reaction conditions, easily available raw materials, no need of any additives and additional ligands, no side reaction, high atom economy, simple operation, high product yield and the like.
Palladium-Catalyzed Synthesis of Benzophenanthrosilines by C?H/C?H Coupling through 1,4-Palladium Migration/Alkene Stereoisomerization
Choi, Seung-Min,Kawakami, Yuka,Shintani, Ryo,Tsuda, Tomohiro
supporting information, p. 8057 - 8061 (2020/03/19)
A new and efficient synthesis of 8H-benzo[e]phenanthro[1,10-bc]silines from 2-((2-(arylethynyl)aryl)silyl)aryl triflates under palladium catalysis has been developed. The reaction mechanism was experimentally investigated and a catalytic cycle involving C
