93228-48-9

Basic information

• Product Name: 3(2H)-Oxazolecarboxylicacid,2-oxo-,methylester(9CI)
• Synonyms: 3(2H)-Oxazolecarboxylicacid,2-oxo-,methylester(9CI)
• CAS NO: 93228-48-9
• Molecular Formula: C₅H₅NO₄
• Molecular Weight: 0
• Product Categories: CARBOXYLICESTER
• Mol File: 93228-48-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3(2H)-Oxazolecarboxylicacid,2-oxo-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Oxazolecarboxylicacid,2-oxo-,methylester(9CI)(93228-48-9)
• EPA Substance Registry System: 3(2H)-Oxazolecarboxylicacid,2-oxo-,methylester(9CI)(93228-48-9)

Safety Data

• Hazardous Substances Data: 93228-48-9(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 27584-70-9 4-oxazolin-2-one 
• 74-88-4 methyl iodide 
• 79-22-1 methyl chloroformate 

Downstream Products

• 1796-27-6 piperidine-1-carboxylic acid methyl ester 
• 5817-70-9 methyl N-benzylcarbamate 

Relevant articles and documents

Carboxylation of N-H/C-H bonds using n-heterocyclic carbene copper(I) complexes

Greenhouse gas makes good: A simple copper-mediated protocol has been developed where N-H or C-H bonds can be directly functionalized using an easily prepared catalyst. The novel [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene] copper(I) hydroxide, [Cu(IPr)(OH)], permits the facile activation and carboxylation of N-H and C-H bonds with pKavalues of less than 27.7 (see scheme).

3-Alkoxycarbonyl-2-oxazolones and Their Homopolymers as Highly Preservable Amino-Protecting Reagents. tert-Butoxy-carbonylation and Benzyloxycarbonylation of Amino Groups

Highly preservable amino protecting reagents derived from the 2-oxazolone moiety as a common activating mediator have been developed. 3-Alkoxycarbonyl-2-oxazolones serve as easily handled reagents for amino protection, including tert-butoxycarbonylation, benzyloxycarbonylation, p-methoxybenzyloxycarbonylation, methoxycarbonylation and ethoxycarbonylation.For example, high yield N-protection of α-amino acids has been smoothly performed by the use of 3-tert-butoxycarbonyl and 3-benzyloxycarbonyl-2-oxazolones in aqueous solution at room temperature.A series of homopolymers, poly(3-alkoxycarbonyl-2-oxazolone), is readily obtainable by radical-initiated chain reaction of the corresponding 4,5-unsubstituted oxazolone monomers (except for the tert-butoxy derivate, which failed to give polymeric compounds), and these were successfully used for amino protection as well.Use of the polymer reagents greatly simplifies the purification procedure, though a longer reaction time is required.Keywords - 3-alkoxycarbonyl-2-oxazolone; poly(2-alkoxycarbonyl-2-oxazolone); 3-tert-butoxycarbonyl-2-oxazolone; 3-benzyloxycarbonyl-2-oxazolone; amino protection