932406-30-9Relevant academic research and scientific papers
Preparation and biological evaluation of key fragments and open analogs of scleritodermin A
Sellanes, Diver,Campot, Francisco,Nú?ez, Ivana,Lin, Gerardo,Espósito, Pablo,Dematteis, Sylvia,Salda?a, Jenny,Domílnguez, Laura,Manta, Eduardo,Serra, Gloria
scheme or table, p. 5384 - 5395 (2010/08/19)
The synthesis of key fragments of scleritodermin A, their assembly, and their biological evaluation as cytotoxic and anthelmintic were performed.Highlights of the synthetic route include formation of the a-ketoamide linkage and use of stereocontrolled reactions.Open analogs of this natural product were obtained using a convergent strategy.
Total synthesis of the originally proposed and revised structures of scleritodermin A
Liu, Sheng,Cui, Yong-Mei,Nan, Fa-Jun
supporting information; experimental part, p. 3765 - 3768 (2009/07/01)
(Chemical Equation Presented) The first total synthesis of the originally proposed and revised structure of scleritodermin A, along with an isomer, were achieved by the use of an α-azido carboxyl group serving as the key α-ketoamide precursor, thus leading to a revision of the structure originally proposed for natural scleritodermin A.
