93247-33-7Relevant academic research and scientific papers
Reformatsky Reaction of Methyl 2-Bromo-3,3,3-trifluoropropanoate. A Synthetic Method for α-Trifluoromethyl-β-hydroxy Esters
Yokozawa, Tsutomu,Ishikawa, Nobuo,Nakai, Takeshi
, p. 1971 - 1974 (1987)
The Reformatsky reagent, prepared from the title bromo-ester and zinc powder in dioxane, is found to be thermally stable enough to undergo addition reactions with aldehydes to afford the α-trifluoromethyl-β-hydroxy esters in high yields.The unique reactiv
Rhenium-Catalyzed Decarboxylative Tri-/Difluoromethylation of Styrenes with Fluorinated Carboxylic Acid-Derived Hypervalent Iodine Reagents
Wang, Yin,Yang, Yunhui,Wang, Congyang
supporting information, p. 1229 - 1233 (2019/11/21)
Herein, unprecedented rhenium-catalyzed decarboxylative oxytri-/difluoromethylation and Heck-type trifluoromethylation of styrenes have been developed by using hypervalent iodine(III) reagents derived from cheap, stable, and easy-handling fluorinated carboxylic acids. Mechanistic studies revealed a radical decarboxylative trifluoromethylation pathway occurring in these reactions.
Preparation and application of 2-(arylmethoxy)isopinocampheols for the asymmetric aldol reaction of 3,3,3-trifluoropropionates
Veeraraghavan Ramachandran,Parthasarathy, Gowrisankar,Gagare, Pravin D.
scheme or table, p. 5359 - 5362 (2011/11/04)
The preparation of 2-(arylmethoxy)isopinocampheols from pinanediol via the DIABL-H reduction of the corresponding aryl aldehyde acetals has been described. A systematic examination of the asymmetric aldol reaction of 3,3,3-trifluoropropionates led to the double diastereoselective aldol reaction of 2-(arylmethoxy)isopinocampheyl 3,3,3-trifluoropropionates providing anti-α-trifluoromethyl-β-hydroxy esters in 63-85% yields, ≥99% anti-selectivity and 80-96% de for the anti-isomer.
