93247-35-9Relevant academic research and scientific papers
A CONVENIENT SYNTHESIS OF ALLENES BY THE REACTION OF PROPARGYL ALCOHOLS WITH GRIGNARD REAGENTS USING 1-CHLORO-2-METHYL-N,N-TETRAMETHYLENEPROPENYLAMINE
Fujisawa, Tamotsu,Iida, Sachio,Sato, Toshio
, p. 4007 - 4010 (1984)
1-Chloro-2-methyl-N,N-tetramethylenepropenylamine was found to be an efficient condensation reagent for the regioselective coupling reaction of propargyl alcohols with Grignard reagents to give allenes in good yields with high chemo- and enantioselectivities.The utility of the reaction was demonstrated in the stereocontrolled synthesis of methyl (E)-2,4,5-tetradecatrienoate, the pheromone of the male dried bean beetle.
