93247-36-0Relevant academic research and scientific papers
Palladium- and Rhodium-Catalyzed Dynamic Kinetic Resolution of Racemic Internal Allenes Towards Chiral Pyrazoles
Hilpert, Lukas J.,Sieger, Simon V.,Haydl, Alexander M.,Breit, Bernhard
, p. 3378 - 3381 (2019)
A complementing Pd- and Rh-catalyzed dynamic kinetic resolution (DKR) of racemic allenes leading to N-allylated pyrazoles is described. Such compounds are of enormous interest in medicinal chemistry as certified drugs and potential drug candidates. The new methods feature high chemo-, regio- and enantioselectivities aside from displaying a broad substrate scope and functional group compatibility. A mechanistic rational accounting for allene racemization and trans-alkene selectivity is discussed.
Selective synthesis of allenes and alkynes through ligand-controlled, palladium-catalyzed decarboxylative hydrogenolysis of propargylic formates
Ohmiya, Hirohisa,Yang, Mingyu,Yamauchi, Yoshihiro,Ohtsuka, Yuhki,Sawamura, Masaya
supporting information; experimental part, p. 1796 - 1799 (2010/09/07)
Ligand-controlled regioselective palladium-catalyzed decarboxylative hydrogenolysis of propargylic formates is described. A wide range of allenes and alkynes were obtained by using either 1,2-diphenylphosphinoethane (DPPE) or 1,6-bisdiphenylphosphinohexane (DPPH) as a catalyst ligand.
