159028-45-2

Upstream product

• 67646-68-8 3-methyl-5-phenylpent-1-yne-3-ol 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 2550-26-7 4-Phenyl-2-butanone 
• 4301-14-8 acetylenemagnesium bromide 

Downstream Products

• 882867-12-1 methyl (E)-[2-methoxy-2,5-dimethyl-5-(2-phenylethyl)-1,3-dioxolan-4-ylidene]acetate 
• 93247-36-0 (3-methylpenta-1,2-diene-1,5-diyl)dibenzene 
• 1345594-20-8 (3-methylhepta-3,4-diene-1,7-diyl)dibenzene 
• 110211-32-0 (3-methylnona-3,4-dienyl)benzene 
• 1448195-68-3 C₁₆H₂₂ 
• 55066-46-1 3-methyl-5-phenylpent-1-en-3-yl acetate 
• 882867-15-4 methyl 4-acetyloxy-4-methyl-3-oxo-6-phenylhexanoate 
• 105401-83-0 3-hydroxy-3-methyl-5-phenylpentan-2-one 

Relevant academic research and scientific papers

Palladium- and Rhodium-Catalyzed Dynamic Kinetic Resolution of Racemic Internal Allenes Towards Chiral Pyrazoles

A complementing Pd- and Rh-catalyzed dynamic kinetic resolution (DKR) of racemic allenes leading to N-allylated pyrazoles is described. Such compounds are of enormous interest in medicinal chemistry as certified drugs and potential drug candidates. The new methods feature high chemo-, regio- and enantioselectivities aside from displaying a broad substrate scope and functional group compatibility. A mechanistic rational accounting for allene racemization and trans-alkene selectivity is discussed.

Facile Alder-Ene Reactions of Silylallenes Involving an Allenic C(sp2)-H Bond

Facile and selective Alder-ene reactions of silylallenes involving the activation of an allenic C(sp2)-H over an allylic C(sp3)-H bond is described. In this ene reaction, the presence of a silyl substituent was found to be critical for the observed reactivity and selectivity since the corresponding alkyl-substituted allenes show different reaction profiles. Computational studies show that the origin of this unusual reactivity is the lower bond dissociation energy of the α-C(sp2)-H bond in silylallenes compared to the corresponding nonsilylated allenes.

Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: Identification of new scaffolds for potent EGFR tyrosine kinase inhibitors

The present study identified several 4-alkynyl and 4-alkenylquinazolines that serve as novel and potent EGFR tyrosine kinase inhibitors. The IC50 values of these compounds are in the nanomolar range. In addition, the 4-(4-phenylbut-1-yn/en-yl)q

PtCl2- and PtCl4-catalyzed cycloisomerization of polyunsaturated precursors

The PtCl2- and PtCl4-catalyzed cycloisomerization of polyunsaturated precursors with different O-protecting groups at the propargylic position is reported. The free hydroxy, O-(bromomethyl)dimethylsilyl, O-methyl and O-propenyl deriv

The Resolution of Tertiary α-Acetylene- Acetate Esters by the Lipase from Candida Cylindracea

The resolution of tertiary alcohols using the Candida cylindracea lipase is explored.In particular strategies are deployed to limit nonenzymatic hydrolysis of the tertiary acetate substrates in buffer, such that a full range of the steric requirements and