93249-45-7

Usage

Uses

4-Methyl-3-(trifluoromethyl)benzaldehyde is used as a building block in synthetic chemistry.

Upstream product

• 1173793-77-5 N-methoxy-N,4-dimethyl-3-(trifluoromethyl)benzamide 
• 261952-01-6 4-methyl-3-(trifluoromethyl)benzoic acid 

Downstream Products

• 1598417-27-6 6-methoxy-4-(2-(4-(4-methyl-3-(trifluoromethyl)benzylamino)piperidin-1-yl)ethyl)quinoline-3-carbonitrile 
• 1598418-15-5 4-(4-methyl-3-trifluoromethyl-benzylamino)-piperidine-1-carboxylic acid tert-butyl ester 
• 1187874-63-0 6-(4-methyl-3-(trifluoromethyl))phenyl-pyridazin-3(2H)-one 
• 1187874-84-5 6-(4-methyl-3-(trifluoromethyl))phenyl-4,5-dihydro-pyridazin-3(2H)-one 

Relevant academic research and scientific papers

Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib

Three novel series of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib were prepared and evaluated in vitro for their cytostatic effects against a human chronic myeloid leukemia (K562), acute myeloid leukemia (HL60), and human leukemia stem-like cell line (KG1a). The structure-activity relationship was analyzed by determining the inhibitory rate of each imatinib analog. Benzene and piperazine rings were necessary groups in these compounds for maintaining inhibitory activities against the K562 and HL60 cell lines. Introducing a trifluoromethyl group significantly enhanced the potency of the compounds against these two cell lines. Surprisingly, some compounds showed significant inhibitory activities against KG1a cells without inhibiting common leukemia cell lines (K562 and HL60). These findings suggest that these compounds are able to inhibit leukemia stem-like cells.

Process for preparing aromatic aldehydes

Aromatic aldehydes are prepared by formylating the corresponding aromatic compounds with urotropine in the presence of hydrogen fluoride. By the described process certain new aromatic aldehydes can be prepared.