1173793-77-5

Basic information

• Product Name: N-methoxy-N,4-dimethyl-3-(trifluoromethyl)benzamide
• Synonyms: N-methoxy-N,4-dimethyl-3-(trifluoromethyl)benzamide
• CAS NO: 1173793-77-5
• Molecular Weight: 247.217
• Mol File: 1173793-77-5.mol

Chemical Properties

• CAS DataBase Reference: N-methoxy-N,4-dimethyl-3-(trifluoromethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methoxy-N,4-dimethyl-3-(trifluoromethyl)benzamide(1173793-77-5)
• EPA Substance Registry System: N-methoxy-N,4-dimethyl-3-(trifluoromethyl)benzamide(1173793-77-5)

Safety Data

• Hazardous Substances Data: 1173793-77-5(Hazardous Substances Data)

Upstream product

• 261952-01-6 4-methyl-3-(trifluoromethyl)benzoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 261952-11-8 4-methyl-3-(trifluoromethyl)benzoyl chloride 

Downstream Products

• 851262-98-1 1-[4-methyl-3-(trifluoromethyl)phenyl]ethanone 
• 93249-45-7 4-methyl-3-(trifluoromethyl)benzaldehyde 
• 1173793-79-7 (1-methyl-1H-tetrazol-5-yl)[4-methyl-3-(trifluoromethyl)phenyl]methanone 

Relevant articles and documents

SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES

The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.

Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib

Three novel series of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib were prepared and evaluated in vitro for their cytostatic effects against a human chronic myeloid leukemia (K562), acute myeloid leukemia (HL60), and human leukemia stem-like cell line (KG1a). The structure-activity relationship was analyzed by determining the inhibitory rate of each imatinib analog. Benzene and piperazine rings were necessary groups in these compounds for maintaining inhibitory activities against the K562 and HL60 cell lines. Introducing a trifluoromethyl group significantly enhanced the potency of the compounds against these two cell lines. Surprisingly, some compounds showed significant inhibitory activities against KG1a cells without inhibiting common leukemia cell lines (K562 and HL60). These findings suggest that these compounds are able to inhibit leukemia stem-like cells.

FUNGICIDE HYDROXIMOYL-TETRAZOLE DERIVATIVES

The present invention relates to hydroximoyl-tetrazole derivatives, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.