93249-59-3

Upstream product

• 139584-40-0 4-Methoxy-benzaldehyde O-(2,4-dinitro-6-trifluoromethyl-phenyl)-oxime 
• 139584-39-7 C₁₄H₇⁽²⁾HF₃N₃O₅ 
• 139584-41-1 3-Bromo-benzaldehyde O-(2,4-dinitro-6-trifluoromethyl-phenyl)-oxime 
• 139584-38-6 Benzaldehyde O-(2,4-dinitro-6-trifluoromethyl-phenyl)-oxime 
• 124-41-4 sodium methylate 
• 139584-42-2 4-Nitro-benzaldehyde O-(2,4-dinitro-6-trifluoromethyl-phenyl)-oxime 

Relevant academic research and scientific papers

Reaction of (E)-O-Arylbenzaldoximes with Sodium Methoxide in Methanol. Effect of Leaving Group upon Nitrile-Forming Transition State

Reactions of (E)-O-arylbenzaldoximes 1-3 with MeONa-MeOH have been studied kinetically.The reactions proceed via competing E2 and SNAr reactions, in which the first step is rate-determining.Although the reactions were strongly influenced by the electronic effect of the β- and O-aryl substituents, they were insensitive to the steric effect of the O-aryl group, except that the SNAr reaction was retarded by the CF3 group of 2.For eliminations from 1-3 promoted by MeONa-MeOH, the kH/kD value increased and the Hammett ρ value decreased with better leaving groups.From these results, the effect of leaving group variation upon the nitrile-forming transition state is assessed.