93250-37-4

Upstream product

• 110-60-1 1,4-diaminobutane 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 87700-93-4 N₁,N₁-(butane-1,4-diyl)bis(benzene-1,2-diamine) 

Relevant academic research and scientific papers

Models for potential dendritic nitric oxide donors: Crystal structures of two 2-nitroanilino precursors and nitric oxide-release behavior of the nitrosated derivatives

Two molecular precursors to dendrimeric materials that could serve as slow and sustained NO-releasing therapeutic agents have been synthesized and characterized. N1,N4-Bis(2-nitrophenyl)butane-1,4-diamine, C16 H18/su

CHEMICAL COMPOUNDS

Compounds that are useful as modulators of transmembrane protein 173 (TMEM173), also known as STING (Stimulator of Interferon Genes), and methods for treating Hepatitis B virus-related conditions in mammals by administering such a compound, are disclosed.

POTASSIUM CHANNEL BLOCKING AGENTS

This invention relates to novel potassium channel blocking agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or di

Synthesis of novel 2,2- and 1,1-linked dimeric 'head-to-head' N-alkoxybenzimidazoles

Synthesis of two new types of 'head-to-head' N,N-alkoxy bisbenzimidazoles is described. The proposed intermediate N-oxy benzimidazole from base-induced heterocyclization of N-alkylnitroanilines can be trapped with a biselectrophile (to give an N,N-linked

Bis (benzimidazole) derivatives serving as potassium blocking agents

This invention relates to novel potassium channel blocking agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, in particular asthma, cystic fibrosis, chronic obstructive pulmonary disease and rhinorrhea, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic hearth disease, angina pectoris, coronary hearth disease, traumatic brain injury, psychosis, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labor, baldness, cancer, and immune suppression.

Syntheses and Reactivity of Bisflavins. Oxidation of N-Benzyl-1,4-dihydronicotinamide by Flavins in Aqueous Solution

Several bisflavins linked at the 10,10'-positions of isoalloxazine rings have been synthesized.The kinetics of the oxidation of N-benzyl-1,4-dihydronicotinamide in aqueous solution have been examined.It has been found that each flavin of a bisflavin is considerably influenced by another intramolecular flavin moiety due to the formation of a charge-transfer complex between intramolecularly reduced and oxidized flavins.The formation of the complex depends on the conformation.

UNUSUAL KINETIC BEHAVIOR OF BIS-FLAVIN FOR N-BENZYL-1,4-DIHYDRONICOTINAMIDE (BNAH) REDUCTION IN AN AQUEOUS SOLUTION

Several bis-flavins linked at 10,10'-positions of isoalloxazine rings were synthesized.The reactivity of each flavin of a bis-flavin was found to be considerably influenced by another intramolecular flavin moiety, depending on the conformation of the bis-