93253-73-7

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-1-aza-5-stanna-bicyclo[3.3.3]undecane is used as a reactant for the synthesis of anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenems. It plays a crucial role in the development of new antibiotics to combat drug-resistant bacterial infections.
Used in Organic Synthesis:
5-Chloro-1-aza-5-stanna-bicyclo[3.3.3]undecane is used as a reagent in metal-catalyzed allylic substitution reactions. It facilitates the formation of new carbon-carbon or carbon-heteroatom bonds, which are essential for the synthesis of complex organic molecules and pharmaceuticals.

Upstream product

• 7646-78-8 tin(IV) chloride 
• 120592-07-6 tris(3-trimethylstannylpropyl)amine 
• 753-73-1 dimethyltin dichloride 
• 102-70-5 Triallylamine 

Downstream Products

• 371756-98-8 5-benzyl-1-aza-5-stannabicyclo[3.3.3]undecane 
• 1461-25-2 tetra-n-butyltin(IV) 
• 124738-73-4 S(C₆H₅)Sn((CH₂)3)3N 

Relevant academic research and scientific papers

PENTACOORDINATED TETRAORGANOTIN AND SILICON COMPOUNDS-SYNTHESIS AND STRUCTURES.

Starting from di- and trifunctional Grignard reagents of the general types E(CH//2CH//2CH//2MgCl)//2 (E equals NMe, O, S) and N(CH//2CH//2MgCl)//3 the cyclic organotin and organosilicon compounds R//2M(CH//2CH//2CH//2)//2E and RM(CH//2CH//2CH//2)//3N (M equals Si, Sn; R equals Cl, Br, I, CH//3) are described. X-ray studies confirm these compounds to exhibit pentacoordinated structures with intramolecular donor-acceptor interactions. The strength of these interactions depends from the nature of the substituents bonded to the metal center. The dynamic processes which are observed by nmr investigations are interpreted in terms of a dissociation-inversion mechanism and an 'in-out' equilibrium. First results are reported concerning the preparation of a two nitrogen containing difunctional Grignard reagent and its reaction with tin tetrachloride providing hexacoordinated tin compounds.

Process for the synthesis of 1-aza-5-halo-5-stannabicyclo[3.3.3]undecane carbapenem intermediates

The present invention relates to a process for synthesizing novel intermediates of formula III: wherein R1 is a halogen. The intermediate compounds described herein are useful for the preparation of carbapenem compounds.

1-AZA-5-STANNA-5,5-DIMETHYLBICYCLO1,5>OCTAN UND 1-AZA-5-STANNA-5-METHYLTRICYCLO1,5>UNDECAN, PENTAKOORDINIERTE TETRAORGANOZINNVERBINDUNGEN

The synthesis of Me2Sn(CH2CH2CH2)2NMe and MeSn(CH2CH2CH2)3N is reported.The transannular Sn-N interaction is confirmed by 1H, 13C and 119Sn NMR spectroscopy.