93259-74-6

Usage

Chemical class

Chloro-substituted naphthalenes

Molar mass

Approximately 240.7 g/mol

Industrial applications

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Research applications

Precursor in the production of dyes and other organic compounds

Health hazards

Potential health hazards, classified as a hazardous substance

Handling precautions

Should be handled with care due to its hazardous nature

Upstream product

• 108-86-1 bromobenzene 
• 66-77-3 1-naphthaldehyde 
• 90-11-9 1-Bromonaphthalene 
• 100-52-7 benzaldehyde 
• 642-28-4 phenyl(1-naphthyl)methanol 

Downstream Products

• 1365911-58-5 4-(4-benzylnaphthalen-1-yl)morpholine 
• 54811-20-0 (4-benzylnaphthalen-1-yl)(phenyl)methanone 
• 1242660-59-8 (E)-1-allyl-4-benzylidene-1,4-dihydronaphthalene 
• 1333506-61-8 (E)-diethyl 2-(1-benzylidene-1,2-dihydronaphthalen-2-yl)malonate 
• 1333506-73-2 (E)-diethyl 2-(4-benzylidene-1,4-dihydronaphthalen-1-yl)-2-methyl malonate 
• 1333506-74-3 (E)-diethyl 2-(4-benzylidene-1,4-dihydronaphthalen-1-yl)-2-phenyl malonate 
• 1333506-71-0 (E)-ethyl 2-(1-benzylidene-1,2-dihydronaphthalen-2-yl)-2-cyanoacetate 
• 62875-49-4 2-(naphthalen-1-yl(phenyl)methyl)malononitrile 
• 1333506-75-4 (E)-ethyl 1-(1-benzylidene-1,2-dihydronaphthalen-2-yl)-2-oxocyclo pentane carboxylate 
• 1333506-72-1 (E)-ethyl 2-(1-benzylidene-1,2-dihydronaphthalen-2-yl)-3-oxobutanoate 

Relevant academic research and scientific papers

Pd-catalyzed allylative dearomatisation using Grignard reagents

Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membered heteroaromatic compounds are also demonstrated to be reactive under similar conditions.

Palladium-catalyzed silylation reaction between benzylic halides and silylboronate

An efficient Pd-catalyzed silylation reaction of benzylic halides with silylboronate is reported. In this reaction, primary and secondary benzylic halides could react well with silylboronates to afford benzylic silanes. This reaction accommodates a broad substrate scope and proceeds smoothly under very mild reaction conditions. The corresponding products could be obtained in moderate to high yields and with stereospecificity.

Palladium-catalyzed amination of chloromethylnaphthalene and chloromethylanthracene derivatives with various amines

Palladium-catalyzed amination of chloromethylnaphthalene and chloromethylanthracene derivatives to produce naphthylamines and anthrylamines in satisfactory to good yields has been developed. The unprecedented amination reactions proceeded smoothly under mild conditions in the presence of Pd(PPh3)4 as a catalyst.

Catalyzing methanolysis of alkyl halides in the interior of an amphiphilic molecular basket

(Figure Presented) A molecular basket with four chelate units assembled on a cone-shaped calix[4]arene assumed reversed micelle-like conformation in 5% methanol/carbon tetrachloride. The inwardly facing hydroxyl groups on the chelates concentrated the pol