932711-31-4Relevant articles and documents
Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators
Elhalem, Eleonora,Bellomo, Ana,Cooke, Mariana,Scravaglieri, Antonella,Pearce, Larry V.,Peach, Megan L.,Gandolfi Donadío, Lucía,Kazanietz, Marcelo G.,Comin, María J.
, p. 11418 - 11431 (2021)
DAG-lactones represent useful templates for the design of potent and selective C1 domain ligands for PKC isozymes. The ester moiety at the sn-1 position, a common feature in this template, is relevant for C1 domain interactions, but it represents a labile