932741-18-9

Usage

Uses

Used in Bioconjugation and Chemical Biology Applications:
Propargyl-PEG3-amine serves as a versatile linker in bioconjugation processes, facilitating the attachment of various functional groups to biomolecules. Its compatibility with click chemistry allows for the efficient and specific modification of biological entities for research and therapeutic purposes.
Used in Synthesis of Functionalized PEG Derivatives:
In the field of polymer chemistry, Propargyl-PEG3-amine is utilized as a building block for the synthesis of a variety of functionalized PEG derivatives. These derivatives are employed in numerous applications, including drug delivery, tissue engineering, and the development of diagnostic tools.
Used in Drug Delivery Systems:
Propargyl-PEG3-amine is used as a component in drug delivery systems to enhance the solubility, stability, and targeted delivery of therapeutic agents. Its ability to be functionalized and its low toxicity make it an ideal candidate for the development of advanced drug delivery platforms.
Used in Bioorthogonal Chemistry:
In the realm of bioorthogonal chemistry, Propargyl-PEG3-amine is employed for the selective modification of biomolecules within living systems. Its reactivity with azides through CuAAC reactions enables the precise labeling and manipulation of biological targets without disrupting native biochemical processes.
Used in Click Chemistry Applications:
Propargyl-PEG3-amine is utilized in click chemistry for the rapid and efficient assembly of molecular complexes. Its role in this field is crucial for the development of new chemical entities and materials with specific functions and properties.

Upstream product

• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 
• 106-96-7 propargyl bromide 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 77544-68-4 8-tosyloxy-3,6-dioxaoctanol 
• 208827-90-1 O-propargyl triethylene glycol 
• 888009-94-7 2-[2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate 
• 1192024-83-1 C₁₈H₃₅N₃O₃Si 
• 5197-62-6 2-[2-(chloroethoxy)ethoxy]ethanol 

Downstream Products

• 932741-19-0 2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethanamine 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION

The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.

PYRROLOBENZODIAZEPINE DIMER PRECURSOR AND LIGAND-LINKER CONJUGATE COMPOUND THEREOF

The present invention relates to a pyrrolobenzodiazepine dimer prodrug and a ligand-linker conjugate compound thereof, a composition containing these, and therapeutic use thereof particularly as an anticancer drug. The stability of the compounds themselves and the stability thereof in plasma are excellent and the compounds are advantageous in terms of manifestation of toxicity, and thus the compounds are industrially useful in that it is possible to target proliferative diseases such as cancer, to perform a specific treatment, to maximize the drug efficacy, and to minimize the occurrence of side effects.

AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME

Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.

RAF-DEGRADING CONJUGATE COMPOUNDS

The present disclosure provides, inter alia, RAF-Degrading Conjugate Compounds that are useful in the treatment of cancer and other RAF related diseases. Also provided are, pharmaceutical compositions, methods of treatment, and kits comprising a RAF- Degrading Conjugate Compound.

AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME

Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the methods for treating of diseases associated with an amyloid or amyloid like proteins.

A modular approach to triazole-containing chemical inducers of dimerisation for yeast three-hybrid screening

The yeast three-hybrid (Y3H) approach shows considerable promise for the unbiased identification of novel small molecule-protein interactions. In recent years, it has been successfully used to link a number of bioactive molecules to novel protein binding partners. However despite its potential importance as a protein target identification method, the Y3H technique has not yet been widely adopted, in part due to the challenges associated with the synthesis of the complex chemical inducers of dimerisation (CIDs). The development of a modular approach using potentially "off the shelf" synthetic components was achieved and allowed the synthesis of a family of four triazole-containing CIDs, MTX-Cmpd2.2-2.5. These CIDs were then compared using the Y3H approach with three of them giving a strong positive interaction with a known target of compound 2, TgCDPK1. These results showed that the modular nature of our synthetic strategy may help to overcome the challenges currently encountered with CID synthesis and should contribute to the Y3H approach reaching its full potential as an unbiased target identification strategy.

Design and synthesis of protoporphyrin IX/vitamin B12 molecular hybrids via CuAAC reaction

The design and synthesis of new molecular hybrids composed of protoporphyrin IX (PPIX) and vitamin B12 via copper catalyzed alkyne azide cycloaddition reaction is described. New, clickable aminoazide and aminoalkyne linkers were prepared and subsequently attached to PPIX (via vinyl group) and to vitamin B12 giving desired building blocks. Preliminary results showed that respective water soluble hybrids were formed under CuAAC reaction. Gratifyingly, Cu incorporation into the PPIX core was avoided, which was important for further biological studies. Copyright

Construction of di-scFv through a trivalent alkyne-azide 1,3-dipolar cycloaddition

Heterofunctional azide and alkyne PEG-linkers have been synthesized and site specifically conjugated to scFv via a reactive thiol functionality; two scFv were coupled by copper catalyzed 1,3-dipolar cycloaddition to make divalent scFv (di-scFv) with an inter-scFv distance defined to provide divalent binding; antigen binding was maintained for the di-scFv construct and increased several times compared to that of the parent scFv; the cycloaddition reaction reported herein represents an important ligation strategy to covalently link macromolecular proteins and retain sensitive structural conformations. The Royal Society of Chemistry.