93276-65-4Relevant academic research and scientific papers
MODULATORS OF DOPAMINE NEUROTRANSMISSION
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Page/Page column 38, (2009/12/05)
The present invention relates to novel1-(4H-1,3-benzodioxin-2-yl)methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically asdopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
MODULATORS OF DOPAMINE NEUROTRANSMISSION
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Page/Page column 63-64, (2009/12/05)
The present invention relates to novel 1-(2,3-dihydro-1,4-benzodioxin-2-yl)- methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically as dopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
Inotropic 2-arylimidazo[1,2-a]pyrimidines
Barraclough,Black,Cambridge,Capon,Cox,Firmin,Gerskowitch,Giles,Glen,Hill,Hull,Iyer,Kettle,King,Nobbs,Randall,Skone,Smith,Vine,et al.
, p. 207 - 217 (2007/10/02)
A series of 2-arylimidazo[1,2-a]pyrimidines has been prepared and evaluated for inotropic activity. Three of these heterocycles, ether 19, sulphide 21 and mesylate 24 displayed more potent inotropic effects in vitro than isomazole. The in vivo inotropic p
Imidazopyrimidines and Imidazopyrazines: The Role of Nitrogen Position in Inotropic Activity
Spitzer, Wayne A.,Victor, Frantz,Pollock, G. Don,Hayes, J. Scott
, p. 1590 - 1595 (2007/10/02)
Congestive heart failure is a major medical problem for which existing medicaments have provided limited benefit.Recent new experimental drugs, including imidazo- and imidazopyridines, have both inotropic and vasodilatory properties.Subtle c
