93291-59-9

Upstream product

• 1765-40-8 (bromomethyl)pentafluorobenzene 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 178489-95-7 4-[(4'-methoxy-2,3,5,6-tetrafluorobenzyl)oxy]acetophenone 
• 201294-73-7 1-{2,3-Dihydroxy-3-methyl-5-[4-(2,3,5,6-tetrafluoro-4-methoxy-benzyloxy)-phenyl]-pentanoyl}-piperidine-4-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 201294-71-5 1-{2,3-Dihydroxy-3-[4-(2,3,5,6-tetrafluoro-4-methoxy-benzyloxy)-phenyl]-butyryl}-piperidine-4-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 131693-34-0 methyl cinnamate 
• 131693-32-8 methyl cinnamate 

Relevant academic research and scientific papers

Electrophore mass tag dideoxy DNA sequencing.

Toward a goal of dideoxy sequencing DNA utilizing electrophore labels, we prepared four electrophore-labeled DNA oligonucleotide primers. Each primer has a different electrophore and DNA sequence but a common glycol keto (alpha,beta-dihydroxyketo) release

Release tag compounds producing ketone signal groups

A release tag reagent suitable for use in the chemical analysis of a substance to be detected comprises signal, release, and reactivity groups. A class of release tag compounds that are cleaved to release as signal groups very stable electrophoric ketones which are sufficiently volatile for determination in the gas phase of an analytical reaction mixture is disclosed.

Molecular analytical release tags and their use in chemical analysis

A release tag reagent suitable for use in the chemical analysis of a substance to be detected, which substance contains reactive groups, such as for, but not limited to gas phase detection groups, which reagent comprises three covalently bonded groups: a

Glycol and olefin electrophoric release tags

An "electrophoric release tag" is a molecular labeling reagent which comprises three covalently-connected groups: electrophore/release/ reactivity. This reagent is first covalently attached via its reactivity group to a substance of interest. The subsequent release tag-substance conjugate is detected by chemically cleaving the release group within the release tag, liberating the electrophore for eventual detection by electron capture in the gas phase. Here electrophoric release tags are advanced by the preparation of three similar tags having a glycol release group. One of the glycol tags, N-(pentafluorobenzoyl)-4-piperidylidenyl-acetic acid glycol, is attached to glycine methyl ester as a model analyte. The resulting conjugate is cleaved within 5 minutes by aqueous periodate at room temperature, releasing the electrophore N-(pentafluorobenzoyl)-4-piperidone, for detection. Also a tag with an olefin release group is prepared: m-(pentafluorobenzyloxy)-E-3-methylcinnamoyl chloride. The latter reagent is attached to thymidine as a model analyte and a subsequent methylated conjugate is cleaved within 1 hr by aqueous permanganate/ periodate, releasing the electrophore m-(pentafluorobenzyloxy)-acetophenone for detection.