933-80-2

Basic information

• Product Name: 4,5-Pyrimidinediamine, 6-chloro-2-methyl-
• Synonyms: 4,5-Pyrimidinediamine, 6-chloro-2-methyl-
• CAS NO: 933-80-2
• Molecular Formula: C₅H₇ClN₄
• Molecular Weight: 158.58900
• Product Categories: Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 933-80-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 314.282°C at 760 mmHg (Cal.) ref.
• Flash Point: 143.873°C (Cal.) ref.
• Appearance: No Data Available
• Density: 1.459g/cm3 (Cal.) ref.
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4,5-Pyrimidinediamine, 6-chloro-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Pyrimidinediamine, 6-chloro-2-methyl-(933-80-2)
• EPA Substance Registry System: 4,5-Pyrimidinediamine, 6-chloro-2-methyl-(933-80-2)

Safety Data

• Hazardous Substances Data: 933-80-2(Hazardous Substances Data)

Usage

Uses

6-Chloro-2-methylpyrimidine-4,5-diamine is an intermediate in the synthesis of selective inhibitors of Class I Phosphatidylinositol 3-Kinases.

Upstream product

• 39906-04-2 5-amino-4,6-dichloro-2-methylpyrimidine 

Downstream Products

• 100859-35-6 6-chloro-2-methyl-9H-purine 
• 934-23-6 2-methyl-9H-purine 
• 1335202-47-5 8-(2-chlorophenyl)-6-(4-ethylpiperazin-1-yl)-2-methyl-9H-purine hydrochloride 
• 1335202-39-5 6-chloro-8-(2-chloro-phenyl)-2-methyl-9H-purine 
• 1335202-48-6 8-(2-chlorophenyl)-6-(4-ethylpiperazin-1-yl)-2-methyl-9H-purine 
• 1268607-44-8 [1-(4-methoxyphenyl)ethyl]-2-methylpteridin-4-yl-amine 
• 34244-81-0 2,6,7-trimethylpteridin-4(1H)-one 
• 827031-79-8 4-chloro-2-methylpteridine 

Relevant articles and documents

TRANSGLUTAMINASE 2 (TG2) INHIBITORS

Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit transglutaminase 2 (TG2). Also described herein are methods for using such TG2 inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from TG2 inhibition.

COMPOSITIONS AND METHODS USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE

The present disclosure is directed, in part, to compounds, or pharmaceutically acceptable salts thereof, for the treatment and/or prevention of neurodegenerative disease, mitchonodrial disease, fibrosis, and/or cardiomyopathy.

TANK-BINDING KINASE INHIBITOR COMPOUNDS

Compounds having the following formula (I) and methods of their use and preparation are disclosed: