934-23-6

Basic information

• Product Name: 1H-Purine, 2-methyl- (9CI)
• Synonyms: 1H-Purine, 2-methyl- (9CI);2-Methyl-1H-purine;2-Methyl-9H-purine;2-methyl-7H-purine
• CAS NO: 934-23-6
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.13864
• Product Categories: PYRIMIDINE
• Mol File: 934-23-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.371g/cm³
• Vapor Pressure: 0.0803mmHg at 25°C
• Refractive Index: 1.763
• CAS DataBase Reference: 1H-Purine, 2-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Purine, 2-methyl- (9CI)(934-23-6)
• EPA Substance Registry System: 1H-Purine, 2-methyl- (9CI)(934-23-6)

Safety Data

• Hazardous Substances Data: 934-23-6(Hazardous Substances Data)

Usage

General Description

1H-Purine, 2-methyl- (9CI), also known as 2-Methyl-1H-purine, is a chemical compound that belongs to the purine family. It is a derivative of the purine base, with a methyl group attached to the 2-position of the purine ring. 1H-Purine, 2-methyl- (9CI) is a basic building block of nucleic acids such as DNA and RNA, and is found in a variety of foods and beverages such as coffee and tea. It also serves as a precursor for the synthesis of important biomolecules such as adenosine and adenosine triphosphate (ATP), which play key roles in cellular energy metabolism and signal transduction pathways. 1H-Purine, 2-methyl- (9CI) is also used in pharmaceutical research as a starting material for the synthesis of various nucleoside analogs and other bioactive compounds.

InChI:InChI=1/C6H6N4/c1-4-7-2-5-6(10-4)9-3-8-5/h2-3,5H,1H3

Upstream product

• 100859-35-6 6-chloro-2-methyl-9H-purine 
• 933-80-2 6-chloro-2-methylpyrimidine -4,5-diamine 
• 39906-04-2 5-amino-4,6-dichloro-2-methylpyrimidine 
• 100859-35-6 6-chloro-2-methyl-7⁽⁹⁾H-purine 
• 38917-31-6 2-methyl-1,7-dihydro-purine-6-thione 

Relevant articles and documents

N8-Glycosylated 8-Azapurine and Methylated Purine Nucleobases: Synthesis and Study of Base Pairing Properties

In this report, we present the synthesis of N8-glycosylated 8-aza-2-methylhypoxanthine and 8-aza-6-thiohypoxanthine 2′-deoxynucleosides as well as methylated 2′-deoxynebularine derivatives. In vitro base pairing properties between each modified and canonical nucleobase were studied. As demonstrated by Tm, incorporation of the modified bases in DNA resulted, with few exceptions, in low stability of duplexes. Modified bases studied in this report are preferentially recognized by T (for N8-glycosylated 8-aza-2-methylhypoxanthine and methylated purines) and G (N8-glycosylated 8-aza-2-methylhypoxanthine). The base pair formed between N8-glycosylated 8-aza-6-thiohypoxanthine and N9-glycosylated 2-methyl-6-thiohypoxanthine (X2:X6) showed, to some extent, an orthogonal interaction. Based on Tm studies, the only potential self-pairing system is formed by the N8-glycosylated 8-aza-6-thiohypoxanthine nucleoside (X2) but only in the absence of canonical G and T. This study indicated that the canonical thymine base is the preferential base partner of methylated purine bases.