93316-40-6

Basic information

• Product Name: 2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
• Synonyms: AKOS BC-2972;2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID;TIMTEC-BB SBB012218;2-(benzoyl)-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;2-(oxo-phenylmethyl)-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;2-Benzoyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid;2-phenylcarbonyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
• CAS NO: 93316-40-6
• Molecular Formula: C₁₇H₁₅NO₃
• Molecular Weight: 281.31
• Mol File: 93316-40-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 520°Cat760mmHg
• Flash Point: 268.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.22E-11mmHg at 25°C
• CAS DataBase Reference: 2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID(93316-40-6)
• EPA Substance Registry System: 2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID(93316-40-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 93316-40-6(Hazardous Substances Data)

Usage

General Description

2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID is a chemical compound with the molecular formula C19H17NO4. It belongs to the class of isoquinoline derivatives and is a derivative of benzoyl tetrahydroisoquinoline. 2-BENZOYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID has been studied for its potential pharmacological activities, including its effects on the central nervous system. It has also been investigated for its potential use in the treatment of various medical conditions, such as neurological disorders and addiction. The synthesis and characterization of this compound have been the subject of scientific research, and its properties and potential applications continue to be explored.

InChI:InChI=1/C17H15NO3/c19-16(12-6-2-1-3-7-12)18-11-14-9-5-4-8-13(14)10-15(18)17(20)21/h1-9,15H,10-11H2,(H,20,21)/p-1/t15-/m1/s1

Upstream product

• 41994-51-8 1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1262971-73-2 3-phenyl-5,10-dihydropyrrolo[1,2-b]isoquinoline-1,2-dicarboxylic acid dimethyl ester 

Relevant articles and documents

Novel bifunctional alkylating agents, 5,10-dihydropyrrolo[1,2-b] isoquinoline derivatives, synthesis and biological activity

A series of linear pyrrolo[1,2-b]isoquinoline derivatives was synthesized for antitumor evaluation. The preliminary antitumor studies reveal that both bis(hydroxymethyl) and their bis(alkylcarbamate) derivatives show significant antitumor activity in inhibiting various human tumor cell growth in vitro. 1,2-Bis(hydroxymethyl)-3-methyl-5,10-dihydropyrrolo[1,2-b]isoquinoline (20a) was selected for antitumor studies in animal models. The results show that this agent can induce complete tumor remission or significant suppression in nude mice bearing human breast (MX-1) xenograft and ovarian (SK-OV-3) xenografts, respectively. Alkaline agarose gel shifting assay showed that 20a is able to cross-link with DNA. Studies on the cell cycle inhibition revealed that this agent induces cell arrest at G2/M phase. The results warrant further antitumor investigation against other human tumor growth in animal models.

Chemistry of amino acids. IV. Decarboxylation of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and its derivatives.

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