93321-14-3Relevant articles and documents
Biaryl pyridine palladacycles nitrogen heterocyclic carbene compound and its preparation and use
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Paragraph 0061; 0062, (2017/01/31)
The invention discloses an aryl-pyridine cyclic Pd-N heterocyclic carbene compound. The general formula of the compound is described in the specification, wherein X is selected from Cl, Br and I, L is an N-heterocyclic carbene ligand, and Aryl is an aryl. The invention also discloses a preparation method of the compound. The preparation method comprises the following steps of: adding 2-(4-halogen atom phenyl)-pyridine, imidazolium salt, arylboronic acid, halogenated palladium and alkaline into an organic solvent, heating under the protection of gas, filtering after reaction is finished, drying by distillation, and purifying, thus the aryl-pyridine cyclic Pd-N heterocyclic carbene compound is obtained. The compound can serve as a catalyst and is used for catalyzing reaction between halogenated benzyl alcohol and arylboronic acid to synthesize aryl methyl alcohol. The preparation method has the characteristics of various substrates, mild reaction conditions, high yield, economy and high efficiency and has an important practical value.
Gold-catalyzed 6-exo-dig cycloisomerization: A versatile approach to functionalized phenanthrenes
Shu, Chao,Li, Long,Chen, Cheng-Bin,Shen, Hong-Cheng,Ye, Long-Wu
supporting information, p. 1525 - 1529 (2014/06/09)
A novel gold-catalyzed 6-exo-dig cycloisomerization of o-propargylbiaryls has been developed that provides ready access to functionalized phenanthrenes in largely good to excellent yields. Notable features of this method are readily available starting materials, mild reaction conditions, and broad substrate scope. Golden cat: A novel gold-catalyzed 6-exo-dig cycloisomerization of o-propargylbiaryls has been developed that provides ready access to functionalized phenanthrenes in largely good to excellent yields. Notable features of this method are readily available starting materials, mild reaction conditions, and broad substrate scope.
A new synthetic approach to 6-unsubstituted phenanthridine and phenanthridine-like compounds under mild and metal-free conditions
Tummatorn, Jumreang,Krajangsri, Suppachai,Norseeda, Krissada,Thongsornkleeb, Charnsak,Ruchirawat, Somsak
supporting information, p. 5077 - 5081 (2014/07/08)
A new and mild synthetic approach for the synthesis of 6-unsubstituted phenanthridine and phenanthridine-like compounds under metal-free conditions at room temperature has been developed. The strategy involved a tandem azide rearrangement/intramolecular annulation and oxidation reactions of biarylmethyl azide precursors to obtain the desired products in up to 99% yields with high regioselectivity.
MELANIN PRODUCTION INHIBITOR
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, (2011/10/13)
Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole), and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3's present in the compound corresponds to the number of X's and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
Highly efficient and versatile synthesis of polyarylfluorenes via Pd-catalyzed C-H bond activation
Hwang, Seung Jun,Kim, Hyun Jin,Chang, Sukbok
supporting information; experimental part, p. 4588 - 4591 (2009/12/09)
A facile protocol for the Pd-catalyzed preparative synthesis of fluorene derivatives has been developed. While a wide range of fluorenes were easily obtained with high efficiency and selectivity under mild conditions, excellent functional group tolerance
MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF
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Page/Page column 86, (2008/12/07)
Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.
